Intermediate stage Hodgkin's disease: preliminary results on 210 patients treated with four ABVD chemotherapy cycles plus extended versus involved field radiotherapy.
(2005)
Journal - Anticancer research (Greece )
Abstract :
BACKGROUND: To improve long-term survival by reducing toxicity in intermediate stage Hodgkin's disease patients, we compared the effects of involved field (IF) versus extended field (EF) irradiation administered after four cycles of ABVD regimen. MATERIALS AND METHODS: Two hundred and ten Hodgkin's disease patients, at clinical stage II with risk factors and III without risk factors, were enrolled in the randomized study HD94. After four courses of ABVD regimen, patients who achieved complete remission (CR) or partial remission (PR) were randomly assigned to the IF or EF arm. The Kaplan-Meier method was adopted to estimate overall survival (OS) and relapse-free survival (RFS). RESULTS: After a median follow-up of 78 months (range 13-111 months), OS was 98% and 96%, respectively, in the EF and IF arms; RFS was 94% and 91%, respectively, in the EF and IF arms. Conclusion: We confirm the efficacy of four cycles of ABVD regimen, with suitable dose intensity, and radiotherapy as consolidation therapy, in intermediate stage Hodgkin's disease patients (CR = 99.5% and OS = 95%). We also found that involved field radiotherapy results were as effective as extended field, without acute toxicity.
| ISSN : | 0250-7005 |
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| Mesh Heading : | Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols Bleomycin Combined Modality Therapy Dacarbazine Doxorubicin Female Hodgkin Disease Humans Male Middle Aged Neoplasm Staging Radiotherapy Dosage Risk Factors Vinblastine administration & dosage adverse effects administration & dosage adverse effects administration & dosage adverse effects administration & dosage adverse effects pathology administration & dosage adverse effects |
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| Mesh Heading Relevant : | therapeutic use drug therapy radiotherapy |
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Hodgkin's disease of the nasopharynx: diagnostic and therapeutic approach with a review of the literature.
(2002)
Journal - Annals of hematology (Germany )
Abstract :
The lymphoid tissues of Waldeyer's ring, including the nasopharynx, are rarely involved in Hodgkin's disease (HD). Between March 1977 and July 2001, about 2150 patients affected by HD were observed in our institute; 7 of them (0.32%), all male patients, had HD of the nasopharynx. They had no symptoms and blood tests were normal. All patients were treated with chemotherapy and/or radiotherapy and achieved complete remission. At a median follow-up of 72 months, they are alive and in continuous complete remission. We conclude that Hodgkin's disease of the nasopharynx is a rare and predominantly male disease with a particularly favorable prognosis. Bone marrow biopsy could be avoided. We believe that two to four cycles of a chemotherapeutic regimen and involved field radiotherapy at an intermediate-high dosage (25-30 Gy) could be the first line treatment for these patients.
| ISSN : | 0939-5555 |
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| Mesh Heading : | Adult Combined Modality Therapy Disease-Free Survival Follow-Up Studies Hodgkin Disease Humans Incidence Male Middle Aged Nasopharyngeal Neoplasms Remission Induction therapy therapy |
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| Mesh Heading Relevant : | diagnosis diagnosis |
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Conventional salvage chemotherapy vs. high-dose therapy with autografting for recurrent or refractory Hodgkin's disease patients.
(2000)
Journal - Annals of hematology (GERMANY )
Abstract :
Despite progress that has been made in curing Hodgkin's disease (HD), patients whose first remission is brief and those resistant to first-line chemotherapy still have a poor outcome. We retrospectively reviewed data from 29 patients with HD in first relapse or refractory to first-line chemotherapy. Following failure, all patients received three cycles of ifosfomide, epirubicin, and etoposide (IEV); moreover, 11 patients received a conditioning regimen followed by autografting. Of the 18 patients treated with IEV, eight (44%) are alive; nine died of disease progression, and one died of hematologic toxicity. The 24-month overall survival (OS), relapse-free survival (RFS), and event-free survival (EFS) are 18%, 44%, and 22%, respectively. Of the 11 patients treated with IEV and autografting, ten are alive (90%) and one patient died of progressive disease. The 29-month OS, RFS, and EFS are 91%, 71%, and 56%, respectively. Our results confirm data showing that patients with relapsed or resistant HD achieve a significantly better OS and EFS if treated with high-dose therapy and autografting.
| ISSN : | 0939-5555 |
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| Mesh Heading : | Adult Antineoplastic Combined Chemotherapy Protocols Bone Marrow Transplantation Combined Modality Therapy Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Epirubicin Etoposide Female Hodgkin Disease Humans Ifosfamide Male Middle Aged Salvage Therapy Survival Rate Transplantation Conditioning Transplantation, Autologous therapeutic use toxicity administration & dosage administration & dosage drug therapy radiotherapy administration & dosage mortality |
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| Mesh Heading Relevant : | therapy |
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Hodgkin's disease during pregnancy: diagnostic and therapeutic management.
(1999)
Journal - Fetal diagnosis and therapy (SWITZERLAND )
Abstract :
OBJECTIVES: To evaluate the possibility that women affected by Hodgkin's disease (HD) during their second or third trimester of pregnancy can safely carry their pregnancy to term. METHODS: From 1986 to 1997, 6 women came to our Center during the second trimester of pregnancy and were diagnosed as having HD. Three of these 6 patients were treated with chemotherapy before delivery and 3 of them were kept under observation and started treatment after delivery. RESULTS: All 6 women gave birth to a healthy female. CONCLUSIONS: The pregnancy does not worsen the course of the illness and does not compromise long-term clinical remission and recovery.
| ISSN : | 1015-3837 |
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| Mesh Heading : | Adult Female Hodgkin Disease Humans Pregnancy Pregnancy Complications, Neoplastic Pregnancy Outcome Pregnancy Trimester, Second Remission Induction |
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| Mesh Heading Relevant : | diagnosis drug therapy diagnosis drug therapy |
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Combined modality therapy in advanced Hodgkin's disease: a report on 218 patients with a median follow-up of eight years.
(1998)
Journal - Haematologica (ITALY )
Abstract :
BACKGROUND AND OBJECTIVE: This study was designed to evaluate the efficacy and toxicity of monthly alternating ABVD/MOPP compared to ABVD/OPP regimens in patients with advanced stage Hodgkin's disease (HD), as well as in early stage patients with systemic symptoms and/or bulky disease. DESIGN AND METHODS: 218 patients with previously untreated HD entered this study: 106 patients in arm A (ABVD/MOPP) and 112 in arm B (ABVD/OPP). Patients received eight courses of one of the two regimens after stratification according to the stage. Patients in complete remission (CR) received 20 Gy to the involved field and 40 Gy to the spleen. The actuarial survival curves were performed according to Kaplan and Meier. RESULTS: No statistically significant differences were observed between the two arms in terms of CR rate and toxicity. However, analysis of total relapses revealed that patients treated with ABVD/OPP had a significantly higher likelihood of achieving a second CR compared to patients who entered the ABVD/MOPP arm. INTERPRETATION AND CONCLUSIONS: Both schemes of chemotherapy followed by radiotherapy produce high percentages of CR, low risk of relapse and an acceptable toxicity.
| ISSN : | 0390-6078 |
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| Mesh Heading : | Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Follow-Up Studies Hodgkin Disease Prospective Studies drug therapy radiotherapy |
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| Mesh Heading Relevant : | therapeutic use therapy |
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Combined modality (ABVD plus radiotherapy) versus radiotherapy in the management of early stage (IIA) Hodgkin's disease with mediastinal involvement.
(1992)
Journal - Haematologica (ITALY )
Abstract :
The aim of this study was to establish whether combined modality treatment (ABVD plus radiotherapy) can reduce the risk of relapse in Hodgkin's disease patients with mediastinal involvement, as compared to radiotherapy alone. The results obtained suggest that one course of ABVD before irradiation can reduce the incidence of relapse. These findings, however, should be considered preliminary and need to be confirmed in larger studies.
| ISSN : | 0390-6078 |
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| Mesh Heading : | Adult Antineoplastic Combined Chemotherapy Protocols Bleomycin Dacarbazine Doxorubicin Female Hodgkin Disease Humans Male Mechlorethamine Mediastinal Neoplasms Neoplasm Recurrence, Local Prednisone Procarbazine Prognosis Remission Induction Salvage Therapy Survival Analysis Treatment Outcome Vinblastine Vincristine administration & dosage administration & dosage administration & dosage mortality pathology radiotherapy administration & dosage pathology radiotherapy prevention & control administration & dosage administration & dosage administration & dosage |
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| Mesh Heading Relevant : | therapeutic use drug therapy drug therapy |
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Risk of infertility in patients with Hodgkin's disease treated with ABVD vs MOPP vs ABVD/MOPP.
(1990)
Journal - Haematologica (ITALY )
Abstract :
The gonadal function of 38 patients with Hodgkin's disease (HD) treated with MOPP chemotherapy (12 patients), ABVD (9 patients) and alternating MOPP/ABVD (17 patients) has been retrospectively investigated with semen analysis. Median age of patients was 25 years (range 16-41 years). Azoospermia was found in all patients from the MOPP group (100%), in 3 of the ABVD group (33%) and in 13 of the MOPP/ABVD group (76%). After temporary oligospermia full recovery of spermatogenesis was observed in 67% of patients treated with ABVD, versus 25% of MOPP-treated patients following a prolonged period of azoospermia and oligospermia. Patients receiving MOPP/ABVD scheme had complete recovery of testicular function after oligospermia in 24% of cases. These results confirm the higher gonadal toxicity of the MOPP regimen as compared to others such as ABVD without alkylating agents.
| ISSN : | 0390-6078 |
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| Mesh Heading : | Adolescent Adult Antineoplastic Combined Chemotherapy Protocols Bleomycin Dacarbazine Doxorubicin Hodgkin Disease Humans Infertility, Male Male Mechlorethamine Prednisone Procarbazine Risk Factors Vinblastine Vincristine adverse effects adverse effects adverse effects adverse effects adverse effects adverse effects adverse effects |
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| Mesh Heading Relevant : | adverse effects drug therapy chemically induced |
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