Skeletal scintigraphy with technetium-99m-tetraphenyl porphyrin sulfonate for the detection and determination of osteomyelitis in an animal model.
Journal - Journal of nuclear medicine : official publication, Society of Nuclear Medicine (UNITED STATES )
This article explores the accumulation of 99mTc-tetraphenyl porphyrin sulfonate (TPPS4) at inflammatory sites, especially osteomyelitis, and compares the results with 111In Cl3 and 111In-WBC in an animal model. METHODS: Osteomyelitis was induced in 12 New Zealand white rabbits by injecting staphylococcus aureus in the left tibia. Three weeks later, radiographs confirmed the disease. Two hours later, after injection of 74 MBq 99mTc-TPPS4, scintiphotos of the lower extremities were acquired and repeat scintiphotos were obtained 24 hr after injection of 5.55 MBq 111In Cl3. After these studies, 24- and 48-hr scintiphotos of the lower extremities were acquired after injecting 5.55 MBq 111In-labeled WBC. RESULTS: The left tibia averaged three times the uptake with 99mTc-TPPS4 compared with right tibia; with 111In Cl3 and 111In WBC the ratios are two times. These three radiopharmaceuticals reveal positive images, but the image quality using 99mTc-TPPS4 is better, as would be expected from the more favorable physical characteristics of 99mTc and the higher uptake. CONCLUSION: The traditional combination of three-phase bone and 67Ga-citrate scintigraphy can be replaced by a single injection of 99mTc-TPPS4 with imaging as early as 2 hr. Finally, the use 99mTc-TPPS4 should result in a substantial reduction in radiopharmaceutical cost.
|ISSN : ||0161-5505|
|Mesh Heading : ||Animals Contrast Media Indium Indium Radioisotopes Leukocytes Osteomyelitis Porphyrins Rabbits Radiopharmaceuticals Staphylococcal Infections Technetium Tibia Time Factors diagnostic use diagnostic use|
|Mesh Heading Relevant : ||radionuclide imaging diagnostic use diagnostic use radionuclide imaging diagnostic use radionuclide imaging|
Localization of a bronchopleural fistula in a postpneumonectomy patient using ventilation scintigraphy.
Journal - Clinical nuclear medicine (UNITED STATES )
|ISSN : ||0363-9762|
|Mesh Heading : ||Bronchial Fistula Fistula Humans Lung Male Middle Aged Pleural Diseases Pneumonectomy etiology etiology radionuclide imaging etiology|
|Mesh Heading Relevant : ||radionuclide imaging radionuclide imaging radionuclide imaging adverse effects|