Octopamine modulates ionic currents and spiking in dorsal unpaired median (DUM) neurons.
Journal - Neuroreport (ENGLAND )
Modulatory effects of octopamine on ionic currents and spiking in isolated cockroach dorsal unpaired median neurons were investigated by means of the chopped voltage-/current-clamp and the patch-clamp technique. Octopamine increased the spiking frequency at concentrations < or = 10 microM and reduced it at > 10 microM. It enhanced a low voltage-activated Ca2+ current at 1 to 100 microM. At concentrations up to 10 microM two components of Ca2+-activated K+ current were potentiated. At > 10 microM octopamine in addition reduced a high voltage-activated Ca2+ current and the Ca2+-activated K+ current. A membrane permeant cAMP-analogue imitated the effects obtained at high octopamine concentration. Octopamine and cAMP in addition reduced a depolarizing resting current at both low and high concentration. Possible mechanisms and physiological significance are discussed for the opposite effects of octopamine observed at low versus high concentrations.
|ISSN : ||0959-4965|
|Mesh Heading : ||8-Bromo Cyclic Adenosine Monophosphate Action Potentials Animals Calcium Channels Cockroaches Cyclic AMP Ganglia, Invertebrate Neurons Octopamine Potassium Channels Tetrodotoxin pharmacology drug effects physiology drug effects pharmacology physiology drug effects drug effects pharmacology|
|Mesh Heading Relevant : ||physiology physiology physiology pharmacology physiology|