A physiological pharmacokinetic model describing the disposition of lead in the absence and presence of L-ascorbic acid in rats.
Journal - Toxicology letters (NETHERLANDS )
The influence of L-ascorbic acid (As-Ac) on the multiple-tissue disposition of lead has been evaluated. Lead concentrations in femur, liver, kidney and plasma of rats were monitored over a 120h period after its intravenous bolus administration (1.0 mg/kg) in the absence and presence of As-Ac at steady state. The observed lead concentration-time data in different tissues of the rats, in the absence and presence of As-Ac, have been simulated using a physiological pharmacokinetic modelling technique. In both cases, the predicted lead concentrations in various tissues were in adequate agreement with the observed data. The model developed in the present investigation supports the previous finding that As-Ac may be useful as a prophylactic agent for lead poisoning.
|ISSN : ||0378-4274|
|Mesh Heading : ||Animals Ascorbic Acid Lead Metabolic Clearance Rate Models, Biological Rats Time Factors Tissue Distribution administration & dosage pharmacokinetics|
|Mesh Heading Relevant : ||pharmacology metabolism|
Interaction of L-ascorbic acid on the disposition of lead in rats.
Journal - Pharmacology & toxicology (DENMARK )
L-Ascorbic acid (As-Ac) has been investigated for its potential in the prophylaxis of lead poisoning. Using rats as the animal model, the pharmacokinetics of As-Ac was determined following a single intravenous dose (100 mg/kg) administered through a jugular vein. Plasma As-Ac levels were monitored using an enzyme assisted UV spectrophotometric method. The pharmacokinetic parameters of As-Ac obtained were used to establish a dosage regimen which could maintain its average plasma concentration of about 11 micrograms/ml at steady state in rats. The disposition of lead acetate (1 mg/kg) in rats was studied in the absence and presence of As-Ac at steady state. Lead concentrations were monitored in femur, kidney, liver and plasma over a 120 hr period using flameless atomic absorption spectrophotometry. In presence of As-Ac, femur, kidney and liver demonstrated 56, 22 and 41% respective reductions in their exposure towards lead. In addition, the half-life of lead in femur and plasma was found to be reduced by 27 and 51% respectively.
|ISSN : ||0901-9928|
|Mesh Heading : ||Animals Ascorbic Acid Half-Life Injections, Intravenous Lead Male Rats Rats, Inbred Strains Tissue Distribution administration & dosage pharmacokinetics|
|Mesh Heading Relevant : ||pharmacology pharmacokinetics|