Erythrocytic ouabain-sensitive sodium efflux rate constant in pregnancy.
Journal - European journal of obstetrics, gynecology, and reproductive biology (IRELAND )
To elucidate the physiology of active sodium transport (expressed as erythrocytic ouabian-sensitive sodium efflux rate constant = ERCos) in pregnancy and the influence of dietary sodium intake on that transport, active sodium transport was measured in 52 healthy pregnant women in week 16, 20, 24, 28, 32, 36 or week 38 of gestation. ERCos was not influenced by parity, dietary sodium intake or the development of pregnancy-induced hypertension. A statistical significant shift in ERCos was detected between week 24 and week 28 of gestation accompanied by a shift in intracellular sodium content. The meaning of this change in pregnancy remains unsolved, but an influence of ANP through A-II is suggested.
|ISSN : ||0301-2115|
|Mesh Heading : ||Adult Analysis of Variance Biological Transport, Active Blood Pressure Creatinine Cross-Sectional Studies Erythrocytes European Continental Ancestry Group Female Humans Hypertension Ouabain Potassium Pregnancy Pregnancy Complications, Cardiovascular Pregnancy Trimester, Second Pregnancy Trimester, Third Random Allocation Sodium Sodium, Dietary drug effects drug effects urine blood metabolism metabolism blood blood metabolism urine pharmacology|
|Mesh Heading Relevant : ||metabolism pharmacology metabolism pharmacokinetics administration & dosage|
Effects of angiotensin II on atrial natriuretic peptide in pregnancy.
Journal - American journal of obstetrics and gynecology (UNITED STATES )
To clarify the effects on angiotensin II and blood pressure on plasma atrial natriuretic peptide in pregnancy, angiotensin II was infused in 37 healthy, normotensive pregnant women in week 32 of gestation. Levels of atrial natriuretic peptide were determined with the women in a sitting position 3 days before the test and in the left lateral recumbent position immediately before and after the test. Levels of atrial natriuretic peptide were not influenced by parity or salt intake. They were found to be significantly higher in the left lateral recumbent position than in the sitting position. There was also a significant increase in atrial natriuretic peptide levels during angiotensin II infusion. A dose of angiotensin II less than 1.5 ng/kg/min did not affect atrial natriuretic peptide levels. Rise in atrial natriuretic peptide levels was minimally correlated with rise in mean arterial pressure, as caused by acute vasoconstriction from angiotensin II infusion. Therefore it is suggested that, in pregnancy, the response of atrial natriuretic peptide to angiotensin II is mediated not only by changes in blood pressure but also by angiotensinergic receptor activity in the atria.
|ISSN : ||0002-9378|
|Mesh Heading : ||Adult Angiotensin II Atrial Natriuretic Factor Female Humans Pregnancy|
|Mesh Heading Relevant : ||pharmacology blood blood|