Effect of Commiphora molmol (oleo-gum-resin) on the cytological and biochemical changes induced by cyclophosphamide in mice.
Journal - The American journal of Chinese medicine (UNITED STATES )
The anticlastogenic and biochemical potentials of Commiphora molmol were studied in Swiss albino mice treated with cyclophosphamide (CP). The C.molmol treatment (125-500 mg/kg) showed no mutagenicity. It caused a highly significant and dose-dependent mitodepressant effect in the femoral cells and reduction of RNA levels in hepatic cells as compared with the control. CP treatment showed significant increase in the frequency of micronuclei, cytotoxicity and reduction in the contents of nucleic acids and proteins. Pretreatment with C. molmol could neither alter the biochemical and cytological effects of CP nor show any additive effect of both treatments.
|ISSN : ||0192-415X|
|Mesh Heading : ||Animals Antimutagenic Agents Bone Marrow Bone Marrow Cells Cyclophosphamide DNA Liver Male Medicine, Arabic Mice Mice, Inbred Strains Micronucleus Tests Plant Extracts Plants, Medicinal Protein Biosynthesis RNA drug effects toxicity biosynthesis drug effects metabolism biosynthesis|
|Mesh Heading Relevant : ||pharmacology antagonists & inhibitors pharmacology chemistry|