A M Chauvet Monges

Faculté de Pharmacie

Address Show details

Share |

Keywords

pharmacology pharmacology

Summary Information

Chemico-biological interactions (1)

8,306,749

Maven is an online database of international healthcare professionals. Records are downloadable to Excel or in-house database, with email, postal address and phone/fax contacts.

To view and export full contact details of healthcare professionals you must subscribe to Maven Semantic. To learn more please request a call from our team:

Request a call Brochure

Sources

1H-NMR study of suloctidil-A23187 calcium ionophore interaction.

(1993)

Journal - Chemico-biological interactions (NETHERLANDS )

Abstract :

Suloctidil is a molecule with calcium antagonist properties, whose anti-ionophoretic effect has previously been reported. In the presence of A23187 calcium ionophore free acid (A+), the NMR spectra of suloctidil (S +/-) are modified at the level of H-1 protons and to a lesser degree in the CH3-3 and aromatic regions. Experiments with one of the enantiomers of suloctidil and decoupling investigations led us to postulate the existence of diastereoisomers S+/A+, S-/A+ in the suloctidil +/-/A23187 + mixture. Moreover our results allow the hypothesis that suloctidil and calcium compete for the same binding site of the ionophore molecule.

ISSN :	0009-2797
Mesh Heading :	Calcimycin Drug Interactions Magnetic Resonance Spectroscopy Protons Suloctidil chemistry chemistry
Mesh Heading Relevant :	pharmacology pharmacology