Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis.
Journal - The Journal of clinical investigation (United States )
Bronchus-associated lymphoid tissue (BALT) was originally described as a mucosal lymphoid organ in the lungs of some species. However, while the lungs of naive mice and humans typically lack BALT, pulmonary infection in mice leads to the development of inducible BALT (iBALT), which is located in peribronchial, perivascular, and interstitial areas throughout the lung. Here we investigated whether iBALT forms in patients with a variety of interstitial lung diseases. We show that while iBALT can be found in the lungs of patients suffering from multiple diseases, well-developed iBALT is most prevalent in patients with pulmonary complications of RA and Sjögren syndrome. In these patients, iBALT consisted of numerous B cell follicles containing germinal centers and follicular dendritic cells. A loosely defined T cell area surrounded the B cell follicles while lymphatics and high endothelial venules were found at the B cell/T cell interface. Increased expression of lymphoid-organizing chemokines, such as CXCL13 and CCL21, as well as molecules involved in the immunopathology of RA, such as B cell-activating factor of the TNF family (BAFF), ICOS ligand, and lymphotoxin, correlated with more well-developed iBALT. Finally, the presence of iBALT correlated with tissue damage in the lungs of RA patients, suggesting that iBALT participates in local RA pathogenesis.
|ISSN : ||0021-9738|
|Mesh Heading : ||Adult Aged Arthritis, Rheumatoid Autoantibodies Cell Aggregation Chemokines Cytokines Endothelial Cells Enzyme-Linked Immunosorbent Assay Female Gene Expression Humans Immunohistochemistry Lung Lung Diseases, Interstitial Lymphoid Tissue Male Middle Aged RNA, Messenger Reverse Transcriptase Polymerase Chain Reaction Sjogren's Syndrome immunology pathology analysis genetics metabolism genetics metabolism metabolism pathology genetics pathology complications immunology immunology pathology genetics metabolism complications immunology metabolism|
|Mesh Heading Relevant : ||metabolism metabolism metabolism metabolism|