Calcium-binding proteins in the substantia nigra and ventral tegmental area during development: correlation with dopaminergic compartmentalization.
Journal - Brain research. Developmental brain research (NETHERLANDS )
The importance of calcium in neuronal function has been amply demonstrated in recent years. The discovery of a class of proteins within neurons which bind calcium, therefore, has proven to be a catalyst for the generation of theories and hypotheses regarding mechanisms of neurotoxicity in the CNS. In addition, the distribution of certain calcium-binding proteins changes during neural development, suggesting that they may play a role in organization or pattern generation. We have examined the ontogeny of three related calcium-binding proteins, calbindin-D28, parvalbumin and calretinin, with respect to the ventral and dorsal compartments or tiers of the dopaminergic population in the ventral midbrain. Single and dual-label immunocytochemistry was employed to map the distributions of calcium-binding proteins and tyrosine hydroxylase from E18 through adulthood. The results show that each of the three proteins exhibits a unique developmental sequence and compartment preference, with calbindin D28 clearly related to the later-developing dorsal tier, and parvalbumin and calretinin to the ventral tier of the dopaminergic ventral mesencephalon.
|ISSN : ||0165-3806|
|Mesh Heading : ||Aging Animals Calcium-Binding Protein, Vitamin D-Dependent Calcium-Binding Proteins Cesarean Section Dopamine Embryo, Mammalian Nerve Tissue Proteins Neurons Parvalbumins Rats Rats, Sprague-Dawley Substantia Nigra Tegmentum Mesencephali Tyrosine 3-Monooxygenase metabolism metabolism metabolism metabolism embryology growth & development embryology growth & development metabolism|
|Mesh Heading Relevant : ||metabolism metabolism metabolism metabolism metabolism|