Impact of universal preadolescent vaccination against hepatitis B on antenatal seroprevalence of hepatitis B markers in British Columbia women.
(2003)
Journal - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne (Canada )
Abstract :
Countries with a low risk of hepatitis B (HB) lack data on the effectiveness of universal HB vaccination programs for children. British Columbia began a program in 1992, offering HB vaccination to 11 year olds. We conducted an anonymous, unlinked serologic survey 7 years later, analyzing a random sample of specimens (n = 1215) from women aged 15-44 years who had undergone antenatal rubella testing. Among those aged 15-19 years inclusive there was no evidence of chronic HB (HB surface antigen), the proportion with evidence of acute HB (anti-HB core antibody) was only 0.6% (compared with 6.5% for the entire sample), and evidence of protective immunity was strong: the prevalence of anti-HB surface antibody (anti-HBs) was 79.1% (compared with 41.4% for the entire sample) and the geometric mean titre was 34.9 IU/mL (compared with 0.6-0.8 IU/mL for the older groups [p < 0.001]).
| ISSN : | 0820-3946 |
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| Mesh Heading : | Acute Disease Adolescent Adult Age Distribution Biological Markers British Columbia Child Child Welfare Chronic Disease Female Health Surveys Hepatitis B Hepatitis B Antibodies Hepatitis B Core Antigens Hepatitis B Surface Antigens Humans Immunization Programs Mass Screening Pregnancy Pregnancy Complications, Infectious Prenatal Diagnosis Program Evaluation Risk Factors Seroepidemiologic Studies Women's Health blood epidemiology blood immunology blood blood blood blood immunology |
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| Mesh Heading Relevant : | epidemiology prevention & control standards epidemiology prevention & control |
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Impact of universal preadolescent vaccination against hepatitis B on antenatal seroprevalence of hepatitis B markers in British Columbia women
(2003)
Journal - Canadian Medical Association Journal
Abstract :
COUNTRIES WITH A LOW RISK OF HEPATITIS B (HB) lack data on theeffectiveness of universal HB vaccination programs for children.British Columbia began a program in 1992, offering HB vaccinationto 11 year olds. We conducted an anonymous, unlinked serologicsurvey 7 years later, analyzing a random sample of specimens(n = 1215) from women aged 15–44 years who had undergoneantenatal rubella testing. Among those aged 15–19 yearsinclusive there was no evidence of chronic HB (HB surface antigen),the proportion with evidence of acute HB (anti-HB core antibody)was only 0.6% (compared with 6.5% for the entire sample), andevidence of protective immunity was strong: the prevalence ofanti-HB surface antibody (anti-HBs) was 79.1% (compared with41.4% for the entire sample) and the geometric mean titre was34.9 IU/mL (compared with 0.6–0.8 IU/mL for the oldergroups [p < 0.001]).