The value of a clinical definition for epidemic KS in predicting HIV seropositivity in Africa.
Journal - Journal of acquired immune deficiency syndromes (UNITED STATES )
Kaposi's sarcoma (KS) in African adults can present in endemic (non-HIV-related) and epidemic (HIV-related) forms. We evaluated the usefulness of a clinical case definition for epidemic KS in predicting HIV seropositivity. A total of 235 patients with KS presenting to the Uganda Cancer Institute from January 1, 1988 to March 31, 1990 were evaluated with history and physical examination. Symptomatic patients underwent chest radiography and upper gastrointestinal endoscopy. One hundred seventy-four patients (80%) underwent HIV ELISA testing with Western blot confirmation. The clinical case definition had a 91% sensitivity and a 95% specificity in predicting HIV seropositivity. Oral KS was the most sensitive specific site of involvement in predicting HIV seropositivity. The clinical case definition is useful in assessing patients to determine prognosis and likelihood of responding to aggressive therapy.
|ISSN : ||0894-9255|
|Mesh Heading : ||Adolescent Adult Aged Aged, 80 and over Blotting, Western Disease Outbreaks Enzyme-Linked Immunosorbent Assay Female HIV Seropositivity Humans Informed Consent Male Middle Aged Prognosis Referral and Consultation Sarcoma, Kaposi Sensitivity and Specificity Uganda complications diagnosis epidemiology|
|Mesh Heading Relevant : ||epidemiology etiology|