Journal - Connecticut medicine (United States )
A middle-aged man presented with progressive dyspnea and a pleural effusion. He had slowly progressive bilateral symmetric extremity weakness, mediastinal lymphadenopathy, and splenomegaly. The diagnosis of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-Protein and Skin changes was suspected clinically and confirmed with a bone marrow biopsy. He responded symptomatically to corticosteroids and is awaiting a stem cell transplant.
|ISSN : ||0010-6178|
|Mesh Heading : ||Adrenal Cortex Hormones Bone Marrow Examination Cyclophosphamide Humans Immunosuppressive Agents Male Middle Aged POEMS Syndrome Stem Cell Transplantation Tomography, X-Ray Computed therapeutic use therapeutic use therapeutic use|
|Mesh Heading Relevant : ||diagnosis therapy|
Molecular aspects of the regulation of tyrosine hydroxylase by testosterone.
Journal - Brain research. Molecular brain research (NETHERLANDS )
Previous studies have demonstrated that the sympathetic hypogastric ganglia (HG) are dependent upon the continued presence of testosterone for normal development and maintenance of tyrosine hydroxylase (TH) activity. The regulation of TH by testosterone has been examined further to determine whether the reduction in TH activity following castration is associated with changes in levels of TH protein and mRNA. TH protein was measured by immunotitration of HG homogenates using a TH-specific antibody, and TH-specific mRNA was detected by hybridization of dot blots of total RNA isolated from HG with a cDNA probe coding for TH. The results show that tyrosine hydroxylase activity, protein and mRNA are coordinately reduced in a graded fashion at 1, 2 and 4 weeks following castration. Testosterone replacement therapy immediately following castration prevents the decrease in TH levels. The results indicate that gonadal steroids regulate the biosynthesis of TH in the HG. Testosterone may control TH either directly by interacting with neurons of the HG, or indirectly by altering levels of trophic factors in the target tissues.
|ISSN : ||0169-328X|
|Mesh Heading : ||Animals Enzyme Induction Ganglia, Sympathetic Male Orchiectomy RNA, Messenger Rats Rats, Inbred Strains Testosterone Tyrosine 3-Monooxygenase drug effects biosynthesis physiology genetics|
|Mesh Heading Relevant : ||enzymology pharmacology biosynthesis|