J Ahamed

Bose Institute

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Keywords

enzymology genetics metabolism

Summary Information

Antimicrobial agents and chemotherapy (1)

8,306,749

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Sources

Molecular characterization of the SHV-11 beta-lactamase of Shigella dysenteriae.

(1999)

Journal - Antimicrobial agents and chemotherapy (UNITED STATES )

Abstract :

A beta-lactamase with an M(r) of 29,000 and a pI of 7.6 was partially purified from a clinical isolate of Shigella dysenteriae. The bla gene encoded the SHV-11 enzyme carrying the substitution Leu-->Gln at position 35 and was linked to a strong promoter. This variant, unlike the prototype SHV-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime.

ISSN :	0066-4804
Mesh Heading :	Cloning, Molecular Conjugation, Genetic Escherichia coli Hydrolysis Shigella dysenteriae beta-Lactam Resistance beta-Lactamases genetics enzymology genetics genetics isolation & purification
Mesh Heading Relevant :	enzymology genetics metabolism