Molecular characterization of the SHV-11 beta-lactamase of Shigella dysenteriae.
Journal - Antimicrobial agents and chemotherapy (UNITED STATES )
A beta-lactamase with an M(r) of 29,000 and a pI of 7.6 was partially purified from a clinical isolate of Shigella dysenteriae. The bla gene encoded the SHV-11 enzyme carrying the substitution Leu-->Gln at position 35 and was linked to a strong promoter. This variant, unlike the prototype SHV-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime.
|ISSN : ||0066-4804|
|Mesh Heading : ||Cloning, Molecular Conjugation, Genetic Escherichia coli Hydrolysis Shigella dysenteriae beta-Lactam Resistance beta-Lactamases genetics enzymology genetics genetics isolation & purification|
|Mesh Heading Relevant : ||enzymology genetics metabolism|