[Frequency of micronuclei in erythrocytes of mice subchronic exposed to ionising radiation and nonylphenol]
Journal - Roczniki Panstwowego Zakladu Higieny (Poland )
The aim of the research was to investigate the level of micronuclei induction in reticulocytes and polychromatic erythrocytes of mice following subchronic exposure to X-rays, nonylphenol (NP) or to a combination of both. Male mice Pzh:SFIS were exposed during 8 weeks, 5 day per week to doses 0.05 Gy and 0.10 Gy of X-rays, 25 mg/kg mc and 50 mg/kg bw of nonylphenol as well as to 0.05 Gy + 25 mg/kg bw NP and 0.10 Gy + 50 mg/kg bw NP for combined exposure. Both X-rays and NP, acting alone induced micronuclei in reticulocytes and in polychromatic erythrocytes of mice. Combined X-rays-NP exposure of peripheral blood reticulocytes and bone marrow polychromatic erythrocytes caused enhanced frequency of micronuclei compared to the effect of each agent alone. In bone marrow reticulocytes, combined exposure in lower doses (0.05 Gy + 25 mg/kg bw NP) induced enhanced mutagenic effect. Contrary, after combined exposure to both agents in higher doses (0.10 Gy + 50 mg/kg bw NP), nonylphenol may protected DNA of reticulocytes against damage induced by X-rays.
|ISSN : ||0035-7715|
|Mesh Heading : ||Animals Bone Marrow Cells Dose-Response Relationship, Radiation Erythrocytes Male Mice Micronucleus Tests Mutagens Phenols Time Factors Whole-Body Irradiation X-Rays radiation effects toxicity|
|Mesh Heading Relevant : ||drug effects radiation effects drug effects radiation effects toxicity adverse effects|