EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjects.
Journal - Human psychopharmacology (England )
In this study the effects of the atypical antipsychotics quetiapine and olanzapine, and the typical antipsychotic haloperidol on EEG patterns were retrospectively investigated in 81 patients under stable monotherapy with either drug (quetiapine: n=22, olanzapine: n=37, haloperidol: n=22). These three subgroups were compared with a control group of healthy subjects (n=30) which were matched regarding sex and age. Diagnoses of patients were schizophrenia (DSM-IV 295.xx, n=61), brief psychotic disorder (DSM-IV 298.8, n=9), schizoaffective disorder (DSM-IV 295.70, n=8) and delusional disorder (DSM-IV 297.1, n=3). There were no statistically significant differences regarding demographic characteristics between the groups. Digital EEG recordings were retrieved from a database and visually assessed by two independent investigators, and one blinded regarding medication. One patient from the quetiapine group (5%), 13 olanzapine patients (35%), five of the haloperidol patients (23%) and two subjects of the control group (7%) had an abnormal EEG. Epileptiform activity was observed in four patients (11%) of the olanzapine group, and none in the others. EEG abnormalities were statistically significantly increased with dose in the olanzapine group, in contrast to patients treated with haloperidol, quetiapine or healthy subjects. In conclusion, EEG abnormalities seem to occur rarely in patients treated with quetiapine comparable to the control group, but significantly more often with haloperidol and olanzapine, possibly due to different receptor profiles of these substances. To our knowledge, this is the first electrophysiological investigation comparing the new atypical antipsychotics quetiapine, haloperidol, olanzapine with healthy subjects.Copyright 2003 John Wiley & Sons, Ltd.
|ISSN : ||0885-6222|
|Mesh Heading : ||Adolescent Adult Aged Aged, 80 and over Antipsychotic Agents Benzodiazepines Dibenzothiazepines Dose-Response Relationship, Drug Electroencephalography Female Haloperidol Humans Male Middle Aged Retrospective Studies Seizures Sex Factors administration & dosage administration & dosage administration & dosage administration & dosage chemically induced|
|Mesh Heading Relevant : ||adverse effects adverse effects adverse effects drug effects adverse effects|
[Non-fatal effect of highly toxic amitriptyline level after suicide attempt. A case report]
Journal - Der Nervenarzt (Germany )
Pharmacotherapeutic intervention in psychiatric patients often bears the risk of drug abuse for suicide attempts. Especially intoxication with tricyclic antidepressants, e.g., amitriptyline, may cause severe complications such as cardiac arrhythmia. Even under intensive care conditions, 2-3% of intoxicated patients still die. Here, we report on a depressed female patient who, thanks to timely and intense intervention, survived a suicide attempt with amitriptyline despite highly toxic plasma levels.
|ISSN : ||0028-2804|
|Mesh Heading : ||Adult Amitriptyline Depressive Disorder, Major Dose-Response Relationship, Drug Female Humans Intensive Care Overdose Suicide, Attempted pharmacokinetics blood drug therapy psychology therapy|
|Mesh Heading Relevant : ||poisoning blood psychology|
[Severe therapy refractory depression as initial manifestation of Parkinson disease]
Journal - Psychiatrische Praxis (GERMANY )
A 60-year old female patient was referred to our University hospital with the diagnosis of severe treatment-resistant major depression to perform electroconvulsive therapy (ECT). For almost two years the patient had been treated with several antidepressants and, temporarily, neuroleptics. After showing no favourable response to ECT, the diagnosis of idiopathic Parkinson's disease was made and the patient was treated with L-dopa plus benserazide and pergolide in combination with the monoamine oxidase inhibitor moclobemide. Both depressed mood and motor symptoms showed dramatic improvement under this therapy.
|ISSN : ||0303-4259|
|Mesh Heading : ||Aged Antiparkinson Agents Combined Modality Therapy Dementia Depressive Disorder Diagnosis, Differential Electroconvulsive Therapy Female Humans Middle Aged Parkinson Disease therapeutic use psychology therapy psychology therapy psychology therapy|
|Mesh Heading Relevant : ||diagnosis diagnosis diagnosis|