Arginine stimulation as a measure of insulin reserve & the familial incidence of
(2001)
Abstract :
To classify children and adolescents with diabetes as having type 1 or type 2 diabetes, and to determine how common undiagnosed diabetes is in their siblings and parents. The currently available test to diagnose type 1 vs type 2 diabetes are not always reliable. We propose to use an intravenous arginine stimulation test to measure insulin reserve and thus, differentiate between type 1 and type 2 diabetes in children and adolescents. To determine how common undiagnosed diabetes is in relatives of children and adolescents with type 1 and type 2 diabete.
| Project Number : | 5M01RR000425-310838 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| IRG : | RIRG |
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| Project Terms : | arginine, diabetes mellitus, diagnosis design /evaluation, disease /disorder classification insulin, insulin dependent diabetes mellitus, noninsulin dependent diabetes mellitus adolescence (12-18), child (0-11), clinical research, human subject |
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Arginine stimulation as a measure of insulin reserve & the familial incidence of
(2000)
| Project Number : | 3M01RR000425-31S70838 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| IRG : | RIRG |
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| Project Terms : | arginine, diabetes mellitus, diagnosis design /evaluation, disease /disorder classification insulin, insulin dependent diabetes mellitus, noninsulin dependent diabetes mellitus adolescence (12-18), child (0-11), clinical research, human subject |
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Arginine stimulation as a measure of insulin reserve & the familial incidence of
(2000)
| Project Number : | 3M01RR000425-31S90838 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| IRG : | RIRG |
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| Project Terms : | arginine, diabetes mellitus, diagnosis design /evaluation, disease /disorder classification insulin, insulin dependent diabetes mellitus, noninsulin dependent diabetes mellitus adolescence (12-18), child (0-11), clinical research, human subject |
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BUSERELIN THERAPY OF PRECOCIOUS PUBERTY
(1994)
Abstract :
To study in an open labeled, non-comparative manner the use of Buserelin (GnRH analog) in the treatment of children with precocious puberty. Periodic pituitary and gonadal hormone evaluations and physical examinations will be used to assess the effectiveness of treatment.
| Project Number : | 5M01RR000425-250357 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | child (0-11), gonadotropin releasing factor, hormone therapy, human therapy evaluation, precocious puberty, reproductive system disorder chemotherapy peptide hormone analog human subject |
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GROWTH HORMONE AND CANCER CACHEXIA
(1994)
Abstract :
LAB USE ONLY. To study the effect of daily growth hormone treatment on glucose and leucine turnover and nitrogen balance in malnourished patients with head and neck cancer. Measurements from treatment and non-treatment periods will be compared.
| Project Number : | 5M01RR000425-250411 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | cachexia, growth hormone, head /neck neoplasm, hormone therapy, malnutrition, neoplasm /cancer chemotherapy aminoacid metabolism, cancer complication, glucose metabolism, leucine, nitrogen balance human tissue, nutrition related tag |
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MECHANISMS OF EXERCISE MODULATION OF HUMAN GROWTH
(1994)
Abstract :
LAB USE ONLY. To test the hypothesis that exercise induced growth hormone (GH) release is an important determinant of growth in children. Patterns of GH response to different levels of exercise in children and adults will be compared. Energy expenditure for activity in children will be quantitated.
| Project Number : | 5M01RR000425-250471 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | child physical development, exercise, growth hormone adult human (21+), bioenergetics, child (0-11) |
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THERAPY WITH SYNTHETIC GH AND/OR OXANDROLONE IN TURNER'S SYNDROME
(1993)
Abstract :
To evaluate the safety and efficacy of methionyl-hGH alone and in combination with Oxandrolone in alleviation of growth retardation associated with Turner's Syndrome. Patients will be randomly assigned to one of four treatment groups: no treatment (first 12 months only), Oxandrolone alone, methionyl-hGH alone and methionyl-hGH and Oxandrolone. Treatment effects will be evaluated over a period of five years.
| Project Number : | 5M01RR000425-240312 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | Turner's syndrome, growth hormone, hormone therapy, human therapy evaluation, oxandrolone clinical study /trial, combination chemotherapy, longitudinal human study human subject |
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BUSERELIN THERAPY OF PRECOCIOUS PUBERTY
(1993)
Abstract :
To study in an open labeled, non-comparative manner the use of Buserelin (GnRH analog) in the treatment of children with precocious puberty. Periodic pituitary and gonadal hormone evaluations and physical examinations will be used to assess the effectiveness of treatment.
| Project Number : | 5M01RR000425-240357 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | child (0-11), gonadotropin releasing hormone, hormone therapy, human therapy evaluation, precocious puberty, reproductive system disorder chemotherapy peptide hormone analog, pituitary hormone, reproductive hormone human subject |
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GROWTH HORMONE AND CANCER CACHEXIA
(1993)
Abstract :
LAB USE ONLY. To study the effect of daily growth hormone treatment on glucose and leucine turnover and nitrogen balance in malnourished patients with head and neck cancer. Measurements from treatment and non-treatment periods will be compared.
| Project Number : | 5M01RR000425-240411 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | cachexia, growth hormone, head /neck neoplasm, hormone therapy, human therapy evaluation, malnutrition, neoplasm /cancer chemotherapy aminoacid metabolism, cancer complication, clinical study /trial, glucose metabolism, leucine, nitrogen balance human subject, nutrition related tag |
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MECHANISMS OF EXERCISE MODULATION OF HUMAN GROWTH
(1993)
Abstract :
LAB USE ONLY. To test the hypothesis that exercise induced growth hormone (GH) release is an important determinant of growth in children. Patterns of GH response to different levels of exercise in children and adults will be compared. Energy expenditure for activity in children will be quantitated.
| Project Number : | 5M01RR000425-240471 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | child (0-11), child physical development, exercise, growth hormone adult human (21+), bioenergetics human subject |
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THERAPY WITH GROWTH HORMONE ANALOG AND OXANDROLONE IN TURNER'S SYNDROME
(1992)
Abstract :
To evaluate the safety and efficacy of methionyl-HGH alone and in combination with Oxandrolone in alleviation of growth retardation associated with Turner's Syndrome. Patients will be randomly assigned to one of four treatment groups: no treatment (first 12 months only), Oxandrolone alone, methionyl-hGH alone and methionyl-hGH and Oxandrolone. Treatment effects will be evaluated over a period of five years.
| Project Number : | 2M01RR000425-23A10312 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | Turner's syndrome, growth hormone, hormone therapy, human therapy evaluation, oxandrolone clinical study /trial, combination chemotherapy, longitudinal human study human clinical subject |
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BUSERELIN THERAPY OF PRECOCIOUS PUBERTY
(1992)
Abstract :
To study in an open labeled, non-comparative manner the use of Buserelin (GnRH analog) in the treatment of children with precocious puberty. Periodic pituitary and gonadal hormone evaluations and physical examinations will be used to assess the effectiveness of treatment.
| Project Number : | 2M01RR000425-23A10357 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | gonadotropin releasing hormone, human therapy evaluation, peptide hormone analog, precocious puberty, reproductive system disorder hormone therapy child (0-11), clinical study /trial, reproductive hormone human clinical subject |
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INSULIN MEDIATED EFFECTS ON PROTEIN METABOLISM IN CANCER PATIENTS
(1992)
Abstract :
To study protein breakdown and glucose turnover using infusion of 14C-leucine and 3H-glucose. The effect of insulin infusion on glucose metabolism is studied using euglycemic clamp technique and Bergman Minimal Model. Whether supraphysiologic insulin doses can reverse protein breakdown in cancer patients and its explanation in terms of improved glucose metabolism is to be investigated.
| Project Number : | 2M01RR000425-23A10390 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | glucose metabolism, insulin, neoplasm /cancer, neoplasm /cancer hormone therapy, nutrition aspect of cancer, protein metabolism cachexia, cancer complication, glucose, leucine human clinical subject, nutrition related tag, radiotracer |
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GROWTH HORMONE AND CANCER CACHEXIA
(1992)
Abstract :
To study the effect of daily growth hormone treatment on glucose and leucine turnover and nitrogen balance in malnourished patients with head and neck cancer. Measurements from treatment and non-treatment periods will be compared.
| Project Number : | 2M01RR000425-23A10411 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | cachexia, growth hormone, head /neck neoplasm, human therapy evaluation, malnutrition, neoplasm /cancer hormone therapy aminoacid metabolism, cancer complication, clinical study /trial, glucose metabolism, leucine, nitrogen balance human clinical subject, nutrition related tag |
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BLOOD AND URINE GROWTH FACTOR LEVELS IN PATIENTS WITH VARIOUS DISEASE STATES
(1992)
Abstract :
To measure the levels of nerve growth factor (NGF), epidermal growth factor (EGF) and transforming growth factor (TGF) in blood and urine of patients with various diseases affecting growth and in normal subjects.
| Project Number : | 2M01RR000425-23A10454 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | epidermal growth factor, neurotrophic factor, sign /symptom, transforming growth factor blood chemistry, human clinical subject, urinalysis |
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GROWTH FACTORS AND HORMONES IN FETAL AND INFANT GROWTH
(1992)
Abstract :
To measure levels of growth factors (epidermal growth factor (EGF), insulin like growth factor (IGF) and transforming growth factor (TGF)) in cord blood. To correlate the levels of growth factors with conditions affecting the growth and development of fetuses.
| Project Number : | 2M01RR000425-23A10466 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | epidermal growth factor, growth /development, infant human (0-1 year), insulinlike growth factor, transforming growth factor blood chemistry, umbilical cord female, human clinical subject |
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MECHANISMS OF EXERCISE MODULATION OF HUMAN GROWTH
(1992)
Abstract :
To test the hypothesis that exercise induced growth hormone (GH) release is an important determinant of growth in children. Patterns of GH response to different levels of exercise in children and adults will be compared. Energy expenditure for activity in children will be quantitated.
| Project Number : | 2M01RR000425-23A10471 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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| Project Terms : | exercise, growth /development, growth hormone bioenergetics adult human (21+), child (0-11), human clinical subject |
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KREBS CYCLE METABOLISM IN CANCER
(1991)
| Project Number : | 2S07RR005551-290969 |
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| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
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