GRANULOMA INITIATION FACTORS
(1997)
| Project Number : | 5R01AR031853-11 |
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| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
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| IRG : | GMA |
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GRANULOMA INITIATION FACTORS
(1996)
Abstract :
The long range plan of this research project is to understand the pathomechanisms of human cutaneous hypersensitivity granulomas such as sarcoidosis, metal induced granulomas and tuberculoid leprosy. These diseases create disabling, crippling conditions in patients, and because of a lack of more precise information about the disease process, patients do not receive optimal treatment. This project will be carried out using both in vivo and in vitro murine models in which macrophages aggregate about a nidus, differentiate into epithelioid cells and organize into tightly interdigitating cellular tubercles, closely mimicking the clinical granulomas. The aim is to characterize factors responsible for these initial effects on macrophages. A candidate 20 kD protein called Granuloma Initiating Factor (GIF) has been purified from schistosome egg granulomas and a potent monospecific rabbit antisera raised. The tissue, cellular and subcellular distribution will be sought by immuno- histochemistry with light and microscopy, using anti-GIF IgG. Since: a) GIF, interleukin-1 (IL-lbeta) and tumor necrosis factor (TNF-alpha) induce granulomatous reactions in vitro and in vivo when bound to inert beads; and b) IL-1beta and TNF-alpha-induced in vivo granulomas contain many GIF positive cells, macrophages grown in vitro will be examined for he induction of GIF. Further, the interactions between GIF and the cytokines will be studied by use of ELISA and appropriate antibodies to detect secreted cytokines, and by Northern blot and in situ hybridization analysis to detect cytokine gene expression in macrophages with time after GIF stimulation. Also, the cytokines and other lymphokines will be added individually to GIF-induced macrophage cultures in soluble form to determine how they affect granuloma formation. N-terminal eleven amino acid sequence of GIF is identical to mouse cyclophilin and the GIF molecule cross reacts with antisera to some mouse and human cyclophilins. However, GIF differs from known cyclophilin, as it is concentrated in inflammatory cells of the granulomas and not distributed ubiquitously. In order to verify whether GIF is a cyclophilin-like, granuloma associated protein, the gene for GIF will be cloned from a mouse cDNA library made from mouse granuloma RNA and then expressed to produce recombinant GIF for further biological study. The results of studies with this novel granuloma initiating factor will provide: a) new insights into how macrophages are induced to differentiate into epithelioid cells and to organize into space consuming tubercles; and b) a more logical basis for developing strategies to interdict organized epithelioid cell granulomas in man.
| Project Number : | 5R01AR031853-09 |
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| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
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| IRG : | GMA |
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| Project Terms : | cell differentiation, granuloma, immunology, inflammation, peptidyl prolyl isomerase, protein isoform cell growth regulation, cytokine, macrophage antiserum, enzyme linked immunosorbent assay, genetic library, laboratory mouse, northern blotting |
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GRANULOMA INITIATION FACTORS
(1996)
Abstract :
The long range plan of this research project is to understand the pathomechanisms of human cutaneous hypersensitivity granulomas such as sarcoidosis, metal induced granulomas and tuberculoid leprosy. These diseases create disabling, crippling conditions in patients, and because of a lack of more precise information about the disease process, patients do not receive optimal treatment. This project will be carried out using both in vivo and in vitro murine models in which macrophages aggregate about a nidus, differentiate into epithelioid cells and organize into tightly interdigitating cellular tubercles, closely mimicking the clinical granulomas. The aim is to characterize factors responsible for these initial effects on macrophages. A candidate 20 kD protein called Granuloma Initiating Factor (GIF) has been purified from schistosome egg granulomas and a potent monospecific rabbit antisera raised. The tissue, cellular and subcellular distribution will be sought by immuno- histochemistry with light and microscopy, using anti-GIF IgG. Since: a) GIF, interleukin-1 (IL-lbeta) and tumor necrosis factor (TNF-alpha) induce granulomatous reactions in vitro and in vivo when bound to inert beads; and b) IL-1beta and TNF-alpha-induced in vivo granulomas contain many GIF positive cells, macrophages grown in vitro will be examined for he induction of GIF. Further, the interactions between GIF and the cytokines will be studied by use of ELISA and appropriate antibodies to detect secreted cytokines, and by Northern blot and in situ hybridization analysis to detect cytokine gene expression in macrophages with time after GIF stimulation. Also, the cytokines and other lymphokines will be added individually to GIF-induced macrophage cultures in soluble form to determine how they affect granuloma formation. N-terminal eleven amino acid sequence of GIF is identical to mouse cyclophilin and the GIF molecule cross reacts with antisera to some mouse and human cyclophilins. However, GIF differs from known cyclophilin, as it is concentrated in inflammatory cells of the granulomas and not distributed ubiquitously. In order to verify whether GIF is a cyclophilin-like, granuloma associated protein, the gene for GIF will be cloned from a mouse cDNA library made from mouse granuloma RNA and then expressed to produce recombinant GIF for further biological study. The results of studies with this novel granuloma initiating factor will provide: a) new insights into how macrophages are induced to differentiate into epithelioid cells and to organize into space consuming tubercles; and b) a more logical basis for developing strategies to interdict organized epithelioid cell granulomas in man.
| Project Number : | 5R01AR031853-10 |
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| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | cell differentiation, granuloma, immunology, inflammation, peptidyl prolyl isomerase, protein isoform, sarcoidosis cell growth regulation, cytokine, macrophage antiserum, enzyme linked immunosorbent assay, genetic library, laboratory mouse, northern blotting |
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GRANULOMA INITIATION FACTORS
(1996)
Abstract :
The long range plan of this research project is to understand the pathomechanisms of human cutaneous hypersensitivity granulomas such as sarcoidosis, metal induced granulomas and tuberculoid leprosy. These diseases create disabling, crippling conditions in patients, and because of a lack of more precise information about the disease process, patients do not receive optimal treatment. This project will be carried out using both in vivo and in vitro murine models in which macrophages aggregate about a nidus, differentiate into epithelioid cells and organize into tightly interdigitating cellular tubercles, closely mimicking the clinical granulomas. The aim is to characterize factors responsible for these initial effects on macrophages. A candidate 20 kD protein called Granuloma Initiating Factor (GIF) has been purified from schistosome egg granulomas and a potent monospecific rabbit antisera raised. The tissue, cellular and subcellular distribution will be sought by immuno- histochemistry with light and microscopy, using anti-GIF IgG. Since: a) GIF, interleukin-1 (IL-lbeta) and tumor necrosis factor (TNF-alpha) induce granulomatous reactions in vitro and in vivo when bound to inert beads; and b) IL-1beta and TNF-alpha-induced in vivo granulomas contain many GIF positive cells, macrophages grown in vitro will be examined for he induction of GIF. Further, the interactions between GIF and the cytokines will be studied by use of ELISA and appropriate antibodies to detect secreted cytokines, and by Northern blot and in situ hybridization analysis to detect cytokine gene expression in macrophages with time after GIF stimulation. Also, the cytokines and other lymphokines will be added individually to GIF-induced macrophage cultures in soluble form to determine how they affect granuloma formation. N-terminal eleven amino acid sequence of GIF is identical to mouse cyclophilin and the GIF molecule cross reacts with antisera to some mouse and human cyclophilins. However, GIF differs from known cyclophilin, as it is concentrated in inflammatory cells of the granulomas and not distributed ubiquitously. In order to verify whether GIF is a cyclophilin-like, granuloma associated protein, the gene for GIF will be cloned from a mouse cDNA library made from mouse granuloma RNA and then expressed to produce recombinant GIF for further biological study. The results of studies with this novel granuloma initiating factor will provide: a) new insights into how macrophages are induced to differentiate into epithelioid cells and to organize into space consuming tubercles; and b) a more logical basis for developing strategies to interdict organized epithelioid cell granulomas in man.
| Project Number : | 2R01AR031853-08A2 |
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| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | cell differentiation, granuloma, immunology, inflammation, peptidyl prolyl isomerase, protein isoform cell growth regulation, cytokine, macrophage antiserum, enzyme linked immunosorbent assay, genetic library, laboratory mouse, northern blotting |
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NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
(1992)
Abstract :
The long range plan of this research project is to understand the pathomechanisms of human cutaneous hypersensitivity granulomas, such as sarcoidosis, metal-induced granulomas and tuberculoid leprosy. These diseases create a disabling and crippling condition in patients, and because of a lack of information about the disease process patients do not receive adequate treatment. A new cutaneous model for granulomatous disease has been developed which closely mimics human skin granulomas. It will be used to probe basic pathomechanisms and fill gaps in our knowledge. The hypothesis t be tested proposes that hypersensitivity granulomas evolve from two overlapping and perhaps interdependent events, an initiation event which is independent of the T-cell mediated immune system and promotion event which embodies T-cell mechanisms to expand the efflorescence of clinically apparent granulomas. Using athymic and euthymic littermates, direct experiments are planned to demonstrate that 1) granulomas can be initiated without eliciting evidence of T-cell maturation or function and 2) the initiated granulomatous reaction can be expanded by T-cell functions in euthymic mice and by supplementation of T-cell functions in athymic mice. Furthermore, we will attempt to biochemically characterize both granuloma "initiating" and "promoting" factors. Because there is a need to biochemically distinguish hypersensitivity granulomas from chronic inflammation and foreign body reactions in skin, additional effort will be directed to test some recently described enzymes from activated macrophages in the cutaneous model to better define organized granulomatous inflammation in biochemical terms. It has been recognized that biochemical properties of granulomas in skin may differ from granulomatous lesions in other body sites. In earlier studies eosinophilia along with granuloma formation were transferred by viable cells from euthymic mice to both athymic and euthymic mice. "Eosinophilia transfer factor" which becomes inactive by freeze-drying will be separately isolated from fresh granulomas. It is expected that the findings from the project will provide information about how organized epithelioid cell granulomas are formed in skin and will offer a more cohesive view of the total disease process.
| Project Number : | 5R01AR031853-07 |
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| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE), DISEASES, PATHOLOGIC PROCESSES, INFLAMMATION, IMMUNITY, CELLULAR, CELL-MEDIATED IMMUNE RESPONSES, MODELS, DISEASE MODELS, NEOPLASMS RELATED INTEREST, GRANULOMA, SKIN DISORDERS, SKIN HYPERSENSITIVITY BLOOD AND RE DISORDERS, HISTIOCYTOSIS X, EOSINOPHILIC GRANULOMA, BLOOD AND RE DISORDERS, LEUKOCYTE DISORDERS, EOSINOPHILIA, DISEASES, PATHOLOGIC PROCESSES, INFLAMMATION, FOREIGN BODY (REACTION), IMMUNITY, CELLULAR IMMUNITY ANIMALS, CHORDATES, MAMMALS, RODENTS, MYOMORPHA, ATHYMIC MICE (NUDE), HUMAN, CLINICAL |
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A NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
(1990)
Abstract :
The long range plan of this research project is to understand the pathomechanisms of human cutaneous hypersensitivity granulomas, such as sarcoidosis, metal-induced granulomas and tuberculoid leprosy. These diseases create a disabling and crippling condition in patients, and because of a lack of information about the disease process patients do not receive adequate treatment. A new cutaneous model for granulomatous disease has been developed which closely mimics human skin granulomas. It will be used to probe basic pathomechanisms and fill gaps in our knowledge. The hypothesis t be tested proposes that hypersensitivity granulomas evolve from two overlapping and perhaps interdependent events, an initiation event which is independent of the T-cell mediated immune system and promotion event which embodies T-cell mechanisms to expand the efflorescence of clinically apparent granulomas. Using athymic and euthymic littermates, direct experiments are planned to demonstrate that 1) granulomas can be initiated without eliciting evidence of T-cell maturation or function and 2) the initiated granulomatous reaction can be expanded by T-cell functions in euthymic mice and by supplementation of T-cell functions in athymic mice. Furthermore, we will attempt to biochemically characterize both granuloma "initiating" and "promoting" factors. Because there is a need to biochemically distinguish hypersensitivity granulomas from chronic inflammation and foreign body reactions in skin, additional effort will be directed to test some recently described enzymes from activated macrophages in the cutaneous model to better define organized granulomatous inflammation in biochemical terms. It has been recognized that biochemical properties of granulomas in skin may differ from granulomatous lesions in other body sites. In earlier studies eosinophilia along with granuloma formation were transferred by viable cells from euthymic mice to both athymic and euthymic mice. "Eosinophilia transfer factor" which becomes inactive by freeze-drying will be separately isolated from fresh granulomas. It is expected that the findings from the project will provide information about how organized epithelioid cell granulomas are formed in skin and will offer a more cohesive view of the total disease process.
| Project Number : | 5R01AR031853-05 |
|---|
| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE) HUMAN, CLINICAL |
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NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
(1990)
Abstract :
The long range plan of this research project is to understand the pathomechanisms of human cutaneous hypersensitivity granulomas, such as sarcoidosis, metal-induced granulomas and tuberculoid leprosy. These diseases create a disabling and crippling condition in patients, and because of a lack of information about the disease process patients do not receive adequate treatment. A new cutaneous model for granulomatous disease has been developed which closely mimics human skin granulomas. It will be used to probe basic pathomechanisms and fill gaps in our knowledge. The hypothesis t be tested proposes that hypersensitivity granulomas evolve from two overlapping and perhaps interdependent events, an initiation event which is independent of the T-cell mediated immune system and promotion event which embodies T-cell mechanisms to expand the efflorescence of clinically apparent granulomas. Using athymic and euthymic littermates, direct experiments are planned to demonstrate that 1) granulomas can be initiated without eliciting evidence of T-cell maturation or function and 2) the initiated granulomatous reaction can be expanded by T-cell functions in euthymic mice and by supplementation of T-cell functions in athymic mice. Furthermore, we will attempt to biochemically characterize both granuloma "initiating" and "promoting" factors. Because there is a need to biochemically distinguish hypersensitivity granulomas from chronic inflammation and foreign body reactions in skin, additional effort will be directed to test some recently described enzymes from activated macrophages in the cutaneous model to better define organized granulomatous inflammation in biochemical terms. It has been recognized that biochemical properties of granulomas in skin may differ from granulomatous lesions in other body sites. In earlier studies eosinophilia along with granuloma formation were transferred by viable cells from euthymic mice to both athymic and euthymic mice. "Eosinophilia transfer factor" which becomes inactive by freeze-drying will be separately isolated from fresh granulomas. It is expected that the findings from the project will provide information about how organized epithelioid cell granulomas are formed in skin and will offer a more cohesive view of the total disease process.
| Project Number : | 5R01AR031853-06 |
|---|
| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE), DISEASES, PATHOLOGIC PROCESSES, INFLAMMATION, IMMUNITY, CELLULAR, CELL-MEDIATED IMMUNE RESPONSES, MODELS, DISEASE MODELS, NEOPLASMS RELATED INTEREST, GRANULOMA, SKIN DISORDERS, SKIN HYPERSENSITIVITY BLOOD AND RE DISORDERS, HISTIOCYTOSIS X, EOSINOPHILIC GRANULOMA, BLOOD AND RE DISORDERS, LEUKOCYTE DISORDERS, EOSINOPHILIA, DISEASES, PATHOLOGIC PROCESSES, INFLAMMATION, FOREIGN BODY (REACTION), IMMUNITY, CELLULAR IMMUNITY ANIMALS, CHORDATES, MAMMALS, RODENTS, MYOMORPHA, ATHYMIC MICE (NUDE), HUMAN, CLINICAL |
|---|
A NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
(1990)
Abstract :
The long range plan of this research project is to understand the pathomechanisms of human cutaneous hypersensitivity granulomas, such as sarcoidosis, metal-induced granulomas and tuberculoid leprosy. These diseases create a disabling and crippling condition in patients, and because of a lack of information about the disease process patients do not receive adequate treatment. A new cutaneous model for granulomatous disease has been developed which closely mimics human skin granulomas. It will be used to probe basic pathomechanisms and fill gaps in our knowledge. The hypothesis t be tested proposes that hypersensitivity granulomas evolve from two overlapping and perhaps interdependent events, an initiation event which is independent of the T-cell mediated immune system and promotion event which embodies T-cell mechanisms to expand the efflorescence of clinically apparent granulomas. Using athymic and euthymic littermates, direct experiments are planned to demonstrate that 1) granulomas can be initiated without eliciting evidence of T-cell maturation or function and 2) the initiated granulomatous reaction can be expanded by T-cell functions in euthymic mice and by supplementation of T-cell functions in athymic mice. Furthermore, we will attempt to biochemically characterize both granuloma "initiating" and "promoting" factors. Because there is a need to biochemically distinguish hypersensitivity granulomas from chronic inflammation and foreign body reactions in skin, additional effort will be directed to test some recently described enzymes from activated macrophages in the cutaneous model to better define organized granulomatous inflammation in biochemical terms. It has been recognized that biochemical properties of granulomas in skin may differ from granulomatous lesions in other body sites. In earlier studies eosinophilia along with granuloma formation were transferred by viable cells from euthymic mice to both athymic and euthymic mice. "Eosinophilia transfer factor" which becomes inactive by freeze-drying will be separately isolated from fresh granulomas. It is expected that the findings from the project will provide information about how organized epithelioid cell granulomas are formed in skin and will offer a more cohesive view of the total disease process.
| Project Number : | 2R01AR031853-04A1 |
|---|
| ICD : | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE), GENERAL MEDICINE A STUDY SECTION ENZYME MECHANISMS HUMAN, CLINICAL |
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A NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
(1986)
Abstract :
The long range goal of this project is to investigate the pathophysiology of hypersensitivity granulomas in the skin as they compare with other types of inflammation including foreign body granulomas. A novel cutaneous model has been developed in the mouse by transplantation of granulomas which develop in the liver of mice infected with Schistosoma mansoni. Specifically, we aim to study how granulomas develop in the skin in a microenvironment of T-cell intact or athymic mice and what factors are responsible for elicitation of the unique type of tissue reaction. Morphological and biochemical changes that occur in the tissue transplant will be examined morphologically (by light and electron microscopy) and functionally (by autoradiographic, cytochemical, biochemical and enzymological techniques). The length of time that cutaneous involvement persists will be determined. Modulation of granulomas in the skin after administration of enzyme and mediator inhibitors will be monitored by the various parameters. The findings will be compared with similar observations and measurements previously made in hypersensitivity granulomas of the liver and in nonimmunologic foreign body granulomas experimentally produced in the skin of mice. The information obtained is expected to improve our understanding of granulomatous diseases and to help develop newer and possibly more beneficial ways to treat and control crippling granulomatous diseases of man.
| Project Number : | 5R01AM031853-03 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
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| IRG : | GMA |
|---|
| Project Terms : | DISEASES, PATHOLOGIC PROCESSES, INFLAMMATION, GENERAL MEDICINE A STUDY SECTION, HYPERSENSITIVITY (GENERAL), NEOPLASMS RELATED INTEREST, GRANULOMA, SKIN (GENERAL) BLOOD CELLS, T LYMPHOCYTES, MODELS, DISEASE MODELS HELMINTHS, TREMATODES, SCHISTOSOMA MANSONI, HISTOCHEMISTRY AND CYTOCHEMISTRY (GENERAL), MAMMALS, RODENTS, MYOMORPHA, ATHYMIC MICE (NUDE), OPTICS, MICROSCOPY, ELECTRON, RADIOAUTOGRAPHY |
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A NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
(1986)
Abstract :
The long range goal of this project is to investigate the pathophysiology of hypersensitivity granulomas in the skin as they compare with other types of inflammation including foreign body granulomas. A novel cutaneous model has been developed in the mouse by transplantation of granulomas which develop in the liver of mice infected with Schistosoma mansoni. Specifically, we aim to study how granulomas develop in the skin in a microenvironment of T-cell intact or athymic mice and what factors are responsible for elicitation of the unique type of tissue reaction. Morphological and biochemical changes that occur in the tissue transplant will be examined morphologically (by light and electron microscopy) and functionally (by autoradiographic, cytochemical, biochemical and enzymological techniques). The length of time that cutaneous involvement persists will be determined. Modulation of granulomas in the skin after administration of enzyme and mediator inhibitors will be monitored by the various parameters. The findings will be compared with similar observations and measurements previously made in hypersensitivity granulomas of the liver and in nonimmunologic foreign body granulomas experimentally produced in the skin of mice. The information obtained is expected to improve our understanding of granulomatous diseases and to help develop newer and possibly more beneficial ways to treat and control crippling granulomatous diseases of man.
| Project Number : | 1R01AM031853-01 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | DISEASES, PATHOLOGIC PROCESSES, INFLAMMATION, GENERAL MEDICINE A STUDY SECTION, HYPERSENSITIVITY (GENERAL), NEOPLASMS RELATED INTEREST, GRANULOMA, SKIN (GENERAL) BLOOD CELLS, T LYMPHOCYTES, MODELS, DISEASE MODELS HELMINTHS, TREMATODES, SCHISTOSOMA MANSONI, HISTOCHEMISTRY AND CYTOCHEMISTRY (GENERAL), MAMMALS, RODENTS, MYOMORPHA, ATHYMIC MICE (NUDE), OPTICS, MICROSCOPY, ELECTRON, RADIOAUTOGRAPHY |
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A NEW CUTANEOUS MODEL OF GRANULOMATOUS INFLAMMATION
(1986)
Abstract :
The long range goal of this project is to investigate the pathophysiology of hypersensitivity granulomas in the skin as they compare with other types of inflammation including foreign body granulomas. A novel cutaneous model has been developed in the mouse by transplantation of granulomas which develop in the liver of mice infected with Schistosoma mansoni. Specifically, we aim to study how granulomas develop in the skin in a microenvironment of T-cell intact or athymic mice and what factors are responsible for elicitation of the unique type of tissue reaction. Morphological and biochemical changes that occur in the tissue transplant will be examined morphologically (by light and electron microscopy) and functionally (by autoradiographic, cytochemical, biochemical and enzymological techniques). The length of time that cutaneous involvement persists will be determined. Modulation of granulomas in the skin after administration of enzyme and mediator inhibitors will be monitored by the various parameters. The findings will be compared with similar observations and measurements previously made in hypersensitivity granulomas of the liver and in nonimmunologic foreign body granulomas experimentally produced in the skin of mice. The information obtained is expected to improve our understanding of granulomatous diseases and to help develop newer and possibly more beneficial ways to treat and control crippling granulomatous diseases of man.
| Project Number : | 5R01AM031853-02 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | DISEASES, PATHOLOGIC PROCESSES, INFLAMMATION, GENERAL MEDICINE A STUDY SECTION, HYPERSENSITIVITY (GENERAL), NEOPLASMS RELATED INTEREST, GRANULOMA, SKIN (GENERAL) BLOOD CELLS, T LYMPHOCYTES, MODELS, DISEASE MODELS HELMINTHS, TREMATODES, SCHISTOSOMA MANSONI, HISTOCHEMISTRY AND CYTOCHEMISTRY (GENERAL), MAMMALS, RODENTS, MYOMORPHA, ATHYMIC MICE (NUDE), OPTICS, MICROSCOPY, ELECTRON, RADIOAUTOGRAPHY |
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ALLERGIC SKIN DISEASE COOPERATIVE GROUP
(1985)
Abstract :
To combine the talent and effort of clinical immunologist in the departments of medicine, pediatrics and dermatology to focus on the immunopathological basis of some allergic skin diseases.
| Project Number : | 5P50AI014752-06 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| IRG : | AIRC |
|---|
| Project Terms : | ALLERGY AND IMMUNOLOGY RESEARCH COMMITTEE (NIAID), GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, ATOPIC DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, HUMORAL IMMUNITY, IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS, IMMUNITY, IMMUNOREGULATION, cooperative study HUMAN, CLINICAL |
|---|
ALLERGIC SKIN DISEASE COOPERATIVE GROUP
(1984)
Abstract :
To combine the talent and effort of clinical immunologist in the departments of medicine, pediatrics and dermatology to focus on the immunopathological basis of some allergic skin diseases.
| Project Number : | 2P50AI014752-04 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| IRG : | AIRC |
|---|
| Project Terms : | ALLERGY AND IMMUNOLOGY RESEARCH COMMITTEE (NIAID), GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, ATOPIC DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, HUMORAL IMMUNITY, IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS, IMMUNITY, IMMUNOREGULATION HUMAN, CLINICAL |
|---|
ALLERGIC SKIN DISEASE COOPERATIVE GROUP
(1984)
Abstract :
To combine the talent and effort of clinical immunologist in the departments of medicine, pediatrics and dermatology to focus on the immunopathological basis of some allergic skin diseases.
| Project Number : | 5P50AI014752-05 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| IRG : | AIRC |
|---|
| Project Terms : | ALLERGY AND IMMUNOLOGY RESEARCH COMMITTEE (NIAID), GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, ATOPIC DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, HUMORAL IMMUNITY, IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS, IMMUNITY, IMMUNOREGULATION HUMAN, CLINICAL |
|---|
ALLERGIC SKIN DISEASE COOPERATIVE GROUP
(1981)
Abstract :
To combine the talent and effort of clinical immunologist in the departments of medicine, pediatrics and dermatology to focus on the immunopathological basis of some allergic skin diseases.
| Project Number : | 5P50AI014752-03 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| IRG : | AIRC |
|---|
| Project Terms : | ALLERGY AND IMMUNOLOGY RESEARCH COMMITTEE (NIAID), GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, ATOPIC DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, HUMORAL IMMUNITY, IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS |
|---|
ALLERGIC SKIN DISEASE COOPERATIVE GROUP
(1981)
| Project Number : | 3P50AI014752-03S1 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| IRG : | AIRC |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1981)
Abstract :
This is a continuation of studies on epithelioid cell granuloma using experimental models induced by metals and other substances in man and animals. It is designed to examine granulomatous hypersensitivity in classical immunological terms and to understand biological factors determining sensitization, formation of epithelioid cells and organization of granulomas. The results are expected to provide insight into the pathogenesis of diseases such as tuberculosis and leprosy. Attempts will be made to induce typical organized epithelioid cell granulomas in laboratory animals and to transform mononuclear cells into epithelioid cells in vitro. Comparative chemical characterization of mononuclear cells and epithelioid cells will be achieved by biochemical techniques. Antibodies directed toward a unique protein from epithelioid cells will be used to study epithelioid cells immunohistochemically as well as to provide a diagnostic aid for granulomatous diseases.
| Project Number : | 5R01AM007939-17 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | GENERAL MEDICINE STUDY SECTION, HYPERSENSITIVITY (GENERAL), METABOLIC DISORDERS (INBORN), CHRONIC GRANULAMATOUS DISEASE(OF CHILDREN), NEOPLASMS RELATED INTEREST, GRANULOMA BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, LEPROSY, BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, TUBERCULOSIS, DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE), METAL COMPLEXES, METALS, ALKALINE EARTH METALS, BERYLLIUM, NEOPLASMS CHARACTERISTICS, CELLULAR LEVEL STUDIES (GENERAL), NEOPLASMS IMMUNOLOGY, TISSUE (CELL) CULTURE, TISSUE, EPITHELIUM, neoplastic transformation HISTOCHEMISTRY AND CYTOCHEMISTRY (GENERAL), HUMAN, TISSUES, FLUIDS ETC. FROM NON-RELATED SOURCES OUTSIDE IMMEDIATE PROJECT, MAMMALS, RODENTS, MYOMORPHA, HAMSTERS, OPTICS, MICROSCOPY, ELECTRON, PHYSICAL SEPARATION, CHROMATOGRAPHY, immunochemistry |
|---|
ALLERGIC SKIN DISEASE COOPERATIVE GROUP
(1981)
Abstract :
In order to ensure a sufficient supply of patient/subjects for the total project a coordinated effort will be made to obtain volunteers from various pediatric and dermatology clinics at U.C.S.F. and S.F.G.H. as well as from the dermatology research unit on Ocean Avenue, a Department of Dermatology function and from the Philippino Community where good community relations exist and a large population of severe atopic children are to be found. Patients will have history physicals and routine hemologic and immunologic evaluations before entering the research projects. After the initial workup patients will be placed into the variety of research projects according to their design.
| Project Number : | 1P50AI014752-01 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| IRG : | AIRC |
|---|
| Project Terms : | ALLERGY AND IMMUNOLOGY RESEARCH COMMITTEE (NIAID), GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, ATOPIC DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, HUMORAL IMMUNITY, IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS |
|---|
ALLERGIC SKIN DISEASE COOPERATIVE GROUP
(1981)
Abstract :
To combine the talent and effort of clinical immunologist in the departments of medicine, pediatrics and dermatology to focus on the immunopathological basis of some allergic skin diseases.
| Project Number : | 5P50AI014752-02 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| IRG : | AIRC |
|---|
| Project Terms : | ALLERGY AND IMMUNOLOGY RESEARCH COMMITTEE (NIAID), GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, ATOPIC DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, HUMORAL IMMUNITY, IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1980)
| Project Number : | 2R01AM007939-13 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1980)
Abstract :
This is a continuation of studies on epithelioid cell granuloma using experimental models induced by metals and other substances in man and animals. It is designed to examine granulomatous hypersensitivity in classical immunological terms and to understand biological factors determining sensitization, formation of epithelioid cells and organization of granulomas. The results are expected to provide insight into the pathogenesis of diseases such as tuberculosis and leprosy. Attempts will be made to induce typical organized epithelioid cell granulomas in laboratory animals and to transform mononuclear cells into epithelioid cells in vitro. Comparative chemical characterization of mononuclear cells and epithelioid cells will be achieved by biochemical techniques. Antibodies directed toward a unique protein from epithelioid cells will be used to study epithelioid cells immunohistochemically as well as to provide a diagnostic aid for granulomatous diseases. BIBLIOGRAPHIC REFERENCES: Ling, N-S and Epstein, W.L.: Comparative study of proteins extracted from metal-induced allergic and foreign body granulomas in man. Lab. Invest. 32:706-712, 1975. Black, M.M., Fukuyama, K. and Epstein, W.L.: Induction of human multinucleated monocytes in culture. J. Invest. Derm. 66:90-92, 1976.
| Project Number : | 5R01AM007939-14 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | GENERAL MEDICINE STUDY SECTION, HYPERSENSITIVITY (GENERAL), METABOLIC DISORDERS (INBORN), CHRONIC GRANULAMATOUS DISEASE(OF CHILDREN), NEOPLASMS RELATED INTEREST, GRANULOMA BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, LEPROSY, BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, TUBERCULOSIS, DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE), METAL COMPLEXES, METALS, ALKALINE EARTH METALS, BERYLLIUM, NEOPLASMS CHARACTERISTICS, CELLULAR LEVEL STUDIES (GENERAL), NEOPLASMS IMMUNOLOGY, TISSUE (CELL) CULTURE*, TISSUE, EPITHELIUM, neoplastic transformation HISTOCHEMISTRY AND CYTOCHEMISTRY (GENERAL)*, HUMAN, TISSUES, FLUIDS ETC. FROM NON-RELATED SOURCES OUTSIDE IMMEDIATE PROJECT*, IMMUNOCHEMISTRY (GENERAL)*, MAMMALS, RODENTS, MYOMORPHA, HAMSTERS*, OPTICS, MICROSCOPY, ELECTRON*, PHYSICAL SEPARATION, CHROMATOGRAPHY* |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1980)
Abstract :
This is a continuation of studies on epithelioid cell granuloma using experimental models induced by metals and other substances in man and animals. It is designed to examine granulomatous hypersensitivity in classical immunological terms and to understand biological factors determining sensitization, formation of epithelioid cells and organization of granulomas. The results are expected to provide insight into the pathogenesis of diseases such as tuberculosis and leprosy. Attempts will be made to induce typical organized epithelioid cell granulomas in laboratory animals and to transform mononuclear cells into epithelioid cells in vitro. Comparative chemical characterization of mononuclear cells and epithelioid cells will be achieved by biochemical techniques. Antibodies directed toward a unique protein from epithelioid cells will be used to study epithelioid cells immunohistochemically as well as to provide a diagnostic aid for granulomatous diseases. BIBLIOGRAPHIC REFERENCES: Epstein, W. L.: A Toxicologic Approach to Cutaneous Granulomas, in Advances in Modern Toxicology, Vol. 4 (Marzulli, F. and Maibach, H. I., eds.). John Wiley and Sons, 1977, New York. Kwan-Wong, E. and Epstein, W. L.: The role of T cells in epithelioid cell granuloma formation. Clin. Res. 25:2884, 1977.
| Project Number : | 5R01AM007939-15 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | GENERAL MEDICINE STUDY SECTION, HYPERSENSITIVITY (GENERAL), METABOLIC DISORDERS (INBORN), CHRONIC GRANULAMATOUS DISEASE(OF CHILDREN), NEOPLASMS RELATED INTEREST, GRANULOMA BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, LEPROSY, BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, TUBERCULOSIS, DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE), METAL COMPLEXES, METALS, ALKALINE EARTH METALS, BERYLLIUM, NEOPLASMS CHARACTERISTICS, CELLULAR LEVEL STUDIES (GENERAL), NEOPLASMS IMMUNOLOGY, TISSUE (CELL) CULTURE*, TISSUE, EPITHELIUM, neoplastic transformation HISTOCHEMISTRY AND CYTOCHEMISTRY (GENERAL)*, HUMAN, TISSUES, FLUIDS ETC. FROM NON-RELATED SOURCES OUTSIDE IMMEDIATE PROJECT*, IMMUNOCHEMISTRY, MAMMALS, RODENTS, MYOMORPHA, HAMSTERS*, OPTICS, MICROSCOPY, ELECTRON*, PHYSICAL SEPARATION, CHROMATOGRAPHY* |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1980)
Abstract :
This is a continuation of studies on epithelioid cell granuloma using experimental models induced by metals and other substances in man and animals. It is designed to examine granulomatous hypersensitivity in classical immunological terms and to understand biological factors determining sensitization, formation of epithelioid cells and organization of granulomas. The results are expected to provide insight into the pathogenesis of diseases such as tuberculosis and leprosy. Attempts will be made to induce typical organized epithelioid cell granulomas in laboratory animals and to transform mononuclear cells into epithelioid cells in vitro. Comparative chemical characterization of mononuclear cells and epithelioid cells will be achieved by biochemical techniques. Antibodies directed toward a unique protein from epithelioid cells will be used to study epithelioid cells immunohistochemically as well as to provide a diagnostic aid for granulomatous diseases.
| Project Number : | 5R01AM007939-16 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | GENERAL MEDICINE STUDY SECTION, HYPERSENSITIVITY (GENERAL), METABOLIC DISORDERS (INBORN), CHRONIC GRANULAMATOUS DISEASE(OF CHILDREN), NEOPLASMS RELATED INTEREST, GRANULOMA BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, LEPROSY, BACTERIAL DISEASES, ACTINOMYCETALES INFECTIONS, TUBERCULOSIS, DISEASES, PATHOLOGIC PROCESSES (NOT CLASSIFIED ELSEWHERE), METAL COMPLEXES, METALS, ALKALINE EARTH METALS, BERYLLIUM, NEOPLASMS CHARACTERISTICS, CELLULAR LEVEL STUDIES (GENERAL), NEOPLASMS IMMUNOLOGY, TISSUE (CELL) CULTURE, TISSUE, EPITHELIUM, neoplastic transformation HISTOCHEMISTRY AND CYTOCHEMISTRY (GENERAL), HUMAN, TISSUES, FLUIDS ETC. FROM NON-RELATED SOURCES OUTSIDE IMMEDIATE PROJECT, MAMMALS, RODENTS, MYOMORPHA, HAMSTERS, OPTICS, MICROSCOPY, ELECTRON, PHYSICAL SEPARATION, CHROMATOGRAPHY, immunochemistry |
|---|
IMMUNOLOGIC STUDY OF ALLERGIC SKIN
(1980)
| Project Number : | 5P50AI014752-030001 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| Project Terms : | BLOOD CELLS, B LYMPHOCYTES, BLOOD CELLS, T LYMPHOCYTES, HYPERSENSITIVITY, ATOPIC DERMATITIS, HYPERSENSITIVITY, CONTACT DERMATITIS BLOOD AND RE SYSTEM, MACROPHAGES, CHILDREN, FATTY ACIDS, UNSATURATED, PROSTAGLANDINS, GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, CONTACT DERMATITIS, PLANT DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS, IMMUNOGENETICS (GENERAL), IMMUNOPATHOLOGY (GENERAL), MODELS, BIOLOGICAL, SOCIAL GROUPS, ETHNIC, ASIANS, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING,LEUKOCYTE TYPING HUMAN, CLINICAL, MAMMALS, CARNIVORES, DOGS |
|---|
IMMUNOLOGIC STUDY OF ALLERGIC SKIN
(1979)
| Project Number : | 5P50AI014752-020001 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| Project Terms : | BLOOD CELLS, B LYMPHOCYTES, BLOOD CELLS, T LYMPHOCYTES, HYPERSENSITIVITY, ATOPIC DERMATITIS, HYPERSENSITIVITY, CONTACT DERMATITIS BLOOD AND RE SYSTEM, MACROPHAGES, CHILDREN, FATTY ACIDS, UNSATURATED, PROSTAGLANDINS, GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, CONTACT DERMATITIS, PLANT DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS, IMMUNOGENETICS (GENERAL), IMMUNOPATHOLOGY (GENERAL), MODELS, BIOLOGICAL, SOCIAL GROUPS, ETHNIC, ASIANS, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING,LEUKOCYTE TYPING HUMAN, CLINICAL, MAMMALS, CARNIVORES, DOGS |
|---|
IMMUNOLOGIC STUDY OF ALLERGIC SKIN
(1978)
| Project Number : | 1P50AI014752-010001 |
|---|
| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
|---|
| Project Terms : | BLOOD CELLS, B LYMPHOCYTES, BLOOD CELLS, T LYMPHOCYTES, HYPERSENSITIVITY, ATOPIC DERMATITIS, HYPERSENSITIVITY, CONTACT DERMATITIS BLOOD AND RE SYSTEM, MACROPHAGES, CHILDREN, FATTY ACIDS, UNSATURATED, PROSTAGLANDINS, GLOBULINS, GAMMA GLOBULINS, IMMUNOGLOBULIN E, HYPERSENSITIVITY, CONTACT DERMATITIS, PLANT DERMATITIS, IMMUNITY, CELLULAR IMMUNITY (GENERAL), IMMUNITY, IMMUNOLOGICAL UNRESPONSIVENESS, IMMUNOGENETICS (GENERAL), IMMUNOPATHOLOGY (GENERAL), MODELS, BIOLOGICAL, SOCIAL GROUPS, ETHNIC, ASIANS, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING,LEUKOCYTE TYPING HUMAN, CLINICAL, MAMMALS, CARNIVORES, DOGS |
|---|
MELANOMA CLINICAL COOPERATIVE GROUP
(1977)
Abstract :
The Cooperative Melanoma Clinic at UCSF is staffed by clinician scientists from a wide variety of disciplines. In conjunction with 3 other similar clinics across the country, a broad data base of patient experience is being collected and collated by computer analysis. Patients receive a thorough medical workup, including 1) accurate pathological staging of their primary tumor; 2) an extensive and sophisticated immunological investigation; and 3) evaluation of their urinary DOPA metabolite patterns. These and newer experimental radioisotope methods are expected to provide more meaningful laboratory data for predicting prognosis of this notoriously unpredictable disease and to detect early dissemination of disease as well as to help guide therapy. After the initial workup and staging, patients are placed at random into a variety of treatment regimens utilizing immuno and chemotherapy in double-blind rigorously controlled protocols.
| Project Number : | 2R10CA013671-03 |
|---|
| ICD : | NATIONAL CANCER INSTITUTE |
|---|
| IRG : | CCI |
|---|
| Project Terms : | BIOMEDICAL SYSTEMS AUTOMATED, HEALTH CARE FACILITIES (SYSTEMS) INFORMATION SYSTEMS, CANCER PROGRAM PROJECT COMMITTEE, NEOPLASMS CLASSIFICATION AND STAGING, NEOPLASMS DIAGNOSIS, NEOPLASMS IMMUNIZATION (IMMUNOTHERAPY), PIGMENT CELL NEOPLASMS, MELANOMA, cooperative study BODY REGIONS (GENERAL), DIAGNOSTIC TESTS, EARLY DIAGNOSIS*, HEALTH RECORDS, HEALTH RECORDS (SYSTEMS) AUTOMATED, NEOPLASTIC THERAPY, CANCER CHEMOTHERAPY, POPULATION STUDIES HUMAN, MORBIDITY CHEMISTRY, CLINICAL, URINE CHEMICAL ANALYSIS, HISTOPATHOLOGY (GENERAL)*, HUMAN, CLINICAL, NEOPLASMS RELATED CONTROL TAG |
|---|
COOPERATIVE CLINICAL STUDY OF MALIGNANT MELANOMA
(1977)
| Project Number : | 5R10CA013671-04 |
|---|
| ICD : | NATIONAL CANCER INSTITUTE |
|---|
| IRG : | CCI |
|---|
DERMATOLOGY
(1976)
| Project Number : | 5T01AM005372-11 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | DER |
|---|
GRADUATE TRAINING GRANT
(1976)
| Project Number : | 3T01AM005372-11S1 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | DER |
|---|
GRADUATE TRAINING GRANT
(1976)
| Project Number : | 5T01AM005372-12 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | DER |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1975)
| Project Number : | 3R01AM007939-12S1 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1975)
Abstract :
This project is designed to investigate mechanisms involved in development of granulomatosus hypersensitivity (GHR) immunologically, pathologically and biochemically. In addition chemical and physical factors which control development of GHR are also studied. As an experimental model we use GHR induced by metal (Beryllium oxide) in man, as well as tissue cultured circulating monocytes and other cells from individuals with GHR. Isolation and characterization of substances involved in transformation of precursor cells to organized epitheliod cells will be attempted.
| Project Number : | 5R01AM007939-12 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | GENERAL MEDICINE STUDY SECTION, HYPERSENSITIVITY (GENERAL), NEOPLASMS RELATED INTEREST, GRANULOMA, NEOPLASMS RELATED INTEREST, GRANULOMA CELL COMPONENTS, ENDOPLASMIC RETICULUM, METAL COMPLEXES, METALS, ALKALINE EARTH METALS, BERYLLIUM, SKIN (GENERAL), cell differentiation HUMAN, NON-CLINICAL, HUMAN, NONCLINICAL*, HYDROGEN, TRITIUM*, MAMMALS, RODENTS, GUINEA PIGS*, MAMMALS, RODENTS, HAMSTERS*, OPTICS, MICROSCOPY, ELECTRON*, PYRIMIDINE NUCLEOSIDES, THYMINE NUCLEOSIDES, THYMIDINE, RADIOAUTOGRAPHY* |
|---|
GRADUATE TRAINING GRANT
(1975)
| Project Number : | 5T01AM005372-10 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | DER |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1975)
| Project Number : | 5R01AM007939-10 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | HYPERSENSITIVITY (GENERAL), NEOPLASMS RELATED INTEREST, GRANULOMA CELL COMPONENTS, ENDOPLASMIC RETICULUM, GENERAL MEDICINE STUDY SECTION, METAL COMPLEXES, METALS, ALKALINE EARTH METALS, BERYLLIUM, SKIN (GENERAL), cell differentiation HUMAN, NONCLINICAL*, HYDROGEN, TRITIUM*, MAMMALS, RODENTS, GUINEA PIGS*, OPTICS, MICROSCOPY, ELECTRON* |
|---|
STUDIES OF GRANULOMATOUS HYPERSENSITIVITY
(1975)
| Project Number : | 5R01AM007939-11 |
|---|
| ICD : | NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES |
|---|
| IRG : | GMA |
|---|
| Project Terms : | HYPERSENSITIVITY (GENERAL), NEOPLASMS RELATED INTEREST, GRANULOMA CELL COMPONENTS, ENDOPLASMIC RETICULUM, GENERAL MEDICINE STUDY SECTION, METAL COMPLEXES, METALS, ALKALINE EARTH METALS, BERYLLIUM, SKIN (GENERAL), cell differentiation HUMAN, NONCLINICAL*, HYDROGEN, TRITIUM*, MAMMALS, RODENTS, GUINEA PIGS*, OPTICS, MICROSCOPY, ELECTRON* |
|---|
GAMMAGLOBULIN, THYROID AND SKIN FUNCTION IN LICHEN MYXEDEMATOSUS
(1975)
| Project Number : | 5M01RR000079-130116 |
|---|
| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
|---|
| Project Terms : | BLOOD PROTEINS DISORDERS, GAMMOPATHIES, LICHEN MYXEDEMATOSUS SKIN (GENERAL), thyroid function HUMAN, CLINICAL |
|---|
GAMMAGLOBULIN, THYROID AND SKIN FUNCTION IN LICHEN MYXEDEMATOSUS
(1974)
| Project Number : | 5M01RR000079-120116 |
|---|
| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
|---|
| Project Terms : | BLOOD PROTEINS DISORDERS, GAMMOPATHIES, LICHEN MYXEDEMATOSUS SKIN (GENERAL), thyroid function HUMAN, CLINICAL* |
|---|
ABNORMAL GAMMAGLOBULIN IN LICHEN MYXEDEMATOSUS
(1972)
| Project Number : | 5M01RR000079-100044 |
|---|
| ICD : | NATIONAL CENTER FOR RESEARCH RESOURCES |
|---|
| Project Terms : | GLOBULINS, GAMMA GLOBULINS, IMMUNOPATHOLOGY (GENERAL), MYCOSES, DERMATOMYCOSES, THYROID GLAND DISORDERS, HYPOTHYROIDISM LICHENS HUMAN, CLINICAL* |
|---|
CLINICAL STUDY OF HYPOSENSITIZATION USING URUSHIOL
(1971)
| Project Number : | 2N01BS080632-00668 |
|---|
| ICD : | DIVISION OF BIOLOGICS STANDARDS |
|---|
STUDY OF HYPOSENSITIZATION USING URNSHIOL
(1971)
| Project Number : | 2N01BS080632-00768 |
|---|
| ICD : | DIVISION OF BIOLOGICS STANDARDS |
|---|
CLINICAL STUDY ON HYPOSENSITIZATION USING URUSHIOL
(1970)
| Project Number : | 2N01BS080632-00368 |
|---|
| ICD : | DIVISION OF BIOLOGICS STANDARDS |
|---|
CLINICAL STUDY ON HYPOSENSITIZATION USING URUSHIOL
(1969)
| Project Number : | 1N01BS080632-00068 |
|---|
| ICD : | DIVISION OF BIOLOGICS STANDARDS |
|---|
CLINICAL STUDY ON HYPOSENSITIZATION USING URUSHIOL
(1969)
| Project Number : | 3N01BS080632-00168 |
|---|
| ICD : | DIVISION OF BIOLOGICS STANDARDS |
|---|
CLINICAL STUDY ON HYPOSENSITIZATION USING URUSHIOL
(1969)
| Project Number : | 3N01BS080632-00268 |
|---|
| ICD : | DIVISION OF BIOLOGICS STANDARDS |
|---|