Phosphatase isoenzymes as bone metastasis markers in prostatic carcinoma.
Journal - Clinical biochemistry (CANADA )
Bone alkaline phosphatase (b-ALP) and tartrate resistant acid phosphatase (tr-ACP) are markers of the activity of osteoblasts and osteoclasts, respectively. We have already shown that the serum activity of these isoenzymes was elevated in breast cancer patients with bone metastasis (BM); we show here that the serum activity of b-ALP and tr-ACP were also elevated in prostate cancer patients with BM. Specificity and sensitivity of b-ALP for BM were 0.90 and 0.75, respectively; and for tr-ACP, 0.60 and 0.60, respectively. The accuracy of b-ALP as a BM marker was higher than the accuracy of usual markers of prostatic carcinoma (tartrate labile ACP [tl-ACP], prostatic acid phosphatase [PAP] and prostate specific antigen [PSA]). The highest value predictive of a positive bone scan was obtained with b-ALP (0.88); this increased to 0.97 when b-ALP was coupled with PAP.
|ISSN : ||0009-9120|
|Mesh Heading : ||Acid Phosphatase Alkaline Phosphatase Bone Neoplasms Humans Isoenzymes Male Prostatic Neoplasms Tumor Markers, Biological blood enzymology pathology|
|Mesh Heading Relevant : ||blood secondary blood enzymology blood|
[Evaluation of two serum isoenzyme phosphatases as bone metastasis markers]
Journal - Bulletin du cancer (FRANCE )
Serum activities of bone alkaline phosphatase (b-ALP) and of tartrate resistant acid phosphatase (tr-ACP) were evaluated in 271 cancer patients; 120 of them had bone metastases (BM) and 151 had none. Correlation coefficients, specificities, sensitivities, negative and positive predicting values were computed. They showed the important contribution that these isoenzymes can bring to the diagnosis of BM in 80 patients with prostate cancer, and to the followup of 191 patients with breast cancer. The assay results were analysed in parallel with bone scan and radiography. They were also compared to those of serum antigens: PSA and PAP for prostate cancer, and CEA and CA15.3 for breast cancer. These results clearly indicate that both isoenzymes are better correlated with BM than antigens, these antigens being markers of the whole tumor burden--primary tumor, metastases, recurrence--whereas b-ALP and tr-ACP are specific markers of bone metabolism.
|ISSN : ||0007-4551|
|Mesh Heading : ||Acid Phosphatase Alkaline Phosphatase Bone Neoplasms Breast Neoplasms Carcinoembryonic Antigen Female Humans Male Prostate Prostatic Neoplasms Tumor Markers, Biological blood metabolism pathology analysis chemistry pathology|
|Mesh Heading Relevant : ||blood blood secondary blood|