Hematological toxicity of doxorubicin-containing protocols in dogs with spontaneously occurring malignant tumors.
Journal - Journal of the American Animal Hospital Association (UNITED STATES )
The medical records of 49 dogs with spontaneously occurring malignant tumors treated with doxorubicin-based chemotherapy protocols were evaluated for hematological toxicity. Protocols included vincristine, doxorubicin, and cyclophosphamide (VAC); 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC); doxorubicin and cyclophosphamide (AC); and doxorubicin and dacarbazine (ADIC). Prevalence of Grades 1, 2, or 3 toxicities were less than 30%, and the prevalence of Grade 4 toxicity alone was less than 5%. The frequency of sepsis was less than 2.5% in dogs treated with VAC, FAC, or AC, and it was 15% in dogs treated with ADIC. There were no significant differences in the prevalence or severity of hematological toxicity caused by VAC or AC. Five-fluorouracil, doxorubicin, and cyclophosphamide caused significantly more severe neutropenia than VAC or AC. The low prevalence of hematological complications makes these protocols acceptable for use in practice.
|ISSN : ||0587-2871|
|Mesh Heading : ||Animals Antineoplastic Combined Chemotherapy Protocols Dog Diseases Dogs Doxorubicin Female Leukocyte Count Male Neoplasms Platelet Count Records as Topic Retrospective Studies administration & dosage drug effects veterinary drug therapy drug effects veterinary veterinary|
|Mesh Heading Relevant : ||adverse effects therapeutic use drug therapy adverse effects veterinary|