Cytogenetic findings in two new cases of hepatoblastoma.
(2002)
Journal - Cancer genetics and cytogenetics (United States )
Abstract :
We describe two cases of hepatoblastoma occurring in an 18-month-old boy and a 3-month-old girl. Cytogenetic analysis of the primary tumors revealed gain of 2q and 20 in both cases. In case 1, t(7;8;11) was seen as a secondary abnormality. Other chromosomal aberrations seen in case 2 were unbalanced t(1;1) and t(2;11), resulting in partial gains of 1q and 2q. These results support previous reports that gains of 2q and 20 and rearrangement of chromosome 1 are strongly associated with hepatoblastoma and may be essential for establishing this neoplasm. The 11q and 7q abnormalities may represent a pathway of genetic evolution associated with hepatoblastoma progression.
| ISSN : | 0165-4608 |
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| Mesh Heading : | Chromosome Aberrations Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 8 Female Hepatoblastoma Humans In Situ Hybridization, Fluorescence Infant Karyotyping Liver Neoplasms Male Translocation, Genetic genetics genetics genetics genetics |
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| Mesh Heading Relevant : | Trisomy genetics genetics genetics genetics |
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