Cytogenetic findings in two new cases of hepatoblastoma.
Journal - Cancer genetics and cytogenetics (United States )
We describe two cases of hepatoblastoma occurring in an 18-month-old boy and a 3-month-old girl. Cytogenetic analysis of the primary tumors revealed gain of 2q and 20 in both cases. In case 1, t(7;8;11) was seen as a secondary abnormality. Other chromosomal aberrations seen in case 2 were unbalanced t(1;1) and t(2;11), resulting in partial gains of 1q and 2q. These results support previous reports that gains of 2q and 20 and rearrangement of chromosome 1 are strongly associated with hepatoblastoma and may be essential for establishing this neoplasm. The 11q and 7q abnormalities may represent a pathway of genetic evolution associated with hepatoblastoma progression.
|ISSN : ||0165-4608|
|Mesh Heading : ||Chromosome Aberrations Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 8 Female Hepatoblastoma Humans In Situ Hybridization, Fluorescence Infant Karyotyping Liver Neoplasms Male Translocation, Genetic genetics genetics genetics genetics|
|Mesh Heading Relevant : ||Trisomy genetics genetics genetics genetics|