Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.
Journal - Science (New York, N.Y.) (United States )
The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor-mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1 degrees fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2 degrees fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2 degrees cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal.
|ISSN : ||1095-9203|
|Mesh Heading : ||Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Proteins Female Gene Expression Profiling Gene Expression Regulation, Developmental Genes, Helminth Genes, Reporter Green Fluorescent Proteins Intercellular Signaling Peptides and Proteins Lac Operon Luminescent Proteins MAP Kinase Signaling System Membrane Proteins Mitogen-Activated Protein Kinases Models, Biological Morphogenesis Protein Tyrosine Phosphatases Receptor, Epidermal Growth Factor Recombinant Fusion Proteins Stem Cells Transcription, Genetic Vulva cytology genetics metabolism genetics metabolism genetics metabolism metabolism metabolism cytology metabolism cytology growth & development metabolism|
|Mesh Heading Relevant : ||Signal Transduction growth & development metabolism metabolism metabolism metabolism|