Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.
Journal - Journal of proteome research (United States )
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
|ISSN : ||1535-3893|
|Mesh Heading : ||Animals Biological Markers Blood Proteins Blotting, Western Central Nervous System Electrophoresis, Gel, Two-Dimensional Encephalitis Enzyme-Linked Immunosorbent Assay Humans Huntington Disease Interleukin-6 Mice Protein Array Analysis blood immunology immunology blood|
|Mesh Heading Relevant : ||Proteomics analysis metabolism blood blood|