Antidiarrhoeal activity of the aqueous extract of Terminalia avicennoides roots.
Journal - Phytotherapy research : PTR (England )
The antidiarrhoeal effects of the aqueous root extract of Terminalia avicennoides were evaluated in rodents. Studies were carried out on the isolated rabbit jejunum, gastrointestinal motility in vivo and on castor oil-induced diarrhoea in mice. The results revealed that the extract exhibited a concentration-dependent inhibition of the spontaneous pendular movement of the isolated rabbit jejunum and attenuated acetylcholine induced contractions. The extract (100, 200 and 400 mg/kg) also caused a dose-dependent decrease of gastrointestinal transit and markedly protected mice against castor oil-induced diarrhoea. The intraperitoneal LD(50) of the extract was found to be 871.4-917.4 mg/kg in mice (95% confidence). A preliminary phytochemical screening of the aqueous extract of T. avicennoides roots revealed the presence of tannins, saponins and flavonoids. The results obtained showed that the water extract of T. avicennoides roots may contain some biologically active principles that may be active against diarrhoea and this may be the basis for its use traditionally for gastrointestinal disorders.Copyright 2001 John Wiley & Sons, Ltd.
|ISSN : ||0951-418X|
|Mesh Heading : ||Animals Antidiarrheals Castor Oil Diarrhea Dose-Response Relationship, Drug Female Gastrointestinal Motility Jejunum Male Mice Plant Extracts Rabbits administration & dosage therapeutic use chemically induced administration & dosage pharmacology therapeutic use|
|Mesh Heading Relevant : ||Plants, Medicinal Rosales pharmacology prevention & control drug effects drug effects|