[Clastogenicity effect of ruthenium red in vivo, in bone marrow cells in mice]
(1990)
Journal - Comptes rendus des séances de la Société de biologie et de ses filiales (FRANCE )
Abstract :
The ability of ruthenium red to induce chromosome aberrations in vivo in mammalian somatic cells has been evaluated by the micronucleus test on mouse bone marrow cells. Our results show that this compound, when administered i.p. at a sublethal level, can be considered as a weak clastogen.
| ISSN : | 0037-9026 |
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| Mesh Heading : | Animals Bone Marrow Bone Marrow Cells Cyclophosphamide Female Male Mice Mice, Inbred BALB C Micronucleus Tests Ruthenium Ruthenium Red pharmacology |
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| Mesh Heading Relevant : | Mutation drug effects pharmacology pharmacology |
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[In vitro study of the influence of donor age, nature of mitogen and exposure to X-rays on the proliferation rate of human lymphocytes]
(1990)
Journal - Comptes rendus des séances de la Société de biologie et de ses filiales (FRANCE )
Abstract :
Proliferation of lymphocytes from donors belonging to 4 age groups (2, 25, 45 and 80 years) and exposed, in vitro, to 0 or 2 Gy of X-rays was studied in cultures stimulated by 3 different mitogens. Our results show that these 3 factors (age, irradiation and mitogen) play a role in the frequencies of cells observed in first, second, third or subsequent cell division in 48 or 72 h cultures.
| ISSN : | 0037-9026 |
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| Mesh Heading : | Adult Age Factors Aged Aged, 80 and over Cell Division Child, Preschool Concanavalin A Dose-Response Relationship, Radiation Humans Lectins Lymphocytes Male Middle Aged Mitogens Phytohemagglutinins drug effects pharmacology pharmacology drug effects radiation effects pharmacology |
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| Mesh Heading Relevant : | Plant Lectins radiation effects cytology pharmacology |
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