Management of Heparin-Induced Thrombocytopenia and Heparin-Induced Thrombocytopenia and Thrombosis Syndrome
(1997)
Journal - Clinical and Applied Thrombosis/Hemostasis
Abstract :
Summary: Heparin-induced thrombocytopenia (HIT) is an immunemediated response to heparin in which antibody driven thrombosiscan have a dramatic life-threatening expression. There is muchinterest on this subject including studies on the pathophysiologicmechanism, the clinical managements of the initial stages ofHIT versus the HIT-positive patient requiring continued anticoagulationversus the HIT patient with thrombosis, the pros and cons ofavailable alterr~aci~~ anticoagulants, and the laboratory assaysto aid in the diagnosis of HIT with particular reference tothe sensitivity/specificity of the new heparin-platelet factor4 antibody titer assay. A comprehensive account of these timelyissues is given in this article.
Modulation of Endothelium by Heparin and Related Polyelectrolytes
(1996)
Journal - Clinical and Applied Thrombosis/Hemostasis
Abstract :
The vascular endothelium is an important me diator of the hemostaticbalance. In addition to shielding subendothelial tissue factorfrom flowing blood, endothe lial cells produce a number of substanceswhich favor an antithrombotic state including TFPI and tPA.The ability of polyelectrolytes such as heparin and defibrotideto modulate endothelial function is examined using animal modelsand human studies. Like heparin, defibrotide is observed toincrease plasma TFPI antigen levels. Addi tionally, defibrotideadministration is observed to in crease plasma tPa antigen levelsand to decrease PAI, TF and endothelin levels. Modulation ofendothelial function by defibrotide may account for its beneficialeffect in PAOD.
Fibrinolytic Compromise by Synthetic and Recombinant Thrombin Inhibitors: Implications in the Treatment of Thrombotic Disorders
(1995)
Journal - Clinical and Applied Thrombosis/Hemostasis