Hospital Resource Utilization in Acute Invasive Aspergillosis (AIA) Patients (Pts) Treated with Voriconazole (VOR) or Amphotericin B (CAB).
(2004)
Journal - ASH Annual Meeting Abstracts
Abstract :
AbstractBackground: Treatment of AIA typically involves prolonged hospitalizationand substantial use of intensive care (ICU) resources. Thisstudy compared consumption of hospital resources by AIA ptsreceiving initial treatment with either VOR or CAB.Methods: Data were collected prospectively as part of a clinicaltrial comparing VOR to CAB in AIA of immunocompromised pts,where VOR showed a significant improvement in success and arelative survival benefit (
Herbrecht R et al, NEJM 2002; 347:408–15). Pts in the modified-intent-to-treat populationwith completed resource utilization data were included. Totaldays of hospitalization, days of ICU, and hospitalization-freesurvival days during 12 weeks following initiation of therapywere compared. The impact of survival on resource consumptionwas explored.Results: There were 143 and 131 pts in the VOR and CAB arms,respectively, with resource utilization data. Resource utilizationdata are presented in the Table.
Resource Utilization by Treatment ArmVOR Mean (SD)CAB Mean (SD)Difference (95% CI)Total Hospital Days27.8 (22.7)27.7 (20.8)0.1 (–5.1, 5.3)Total Hospital Days (survivors)30.2 (24.2)33.3 (22.2)–3.1 (–10.3, 4.0)ICU Days5.6 (10.7)8.1 (14.4)–2.5 (–5.5, 0.5)ICU Days (survivors)4.0 (10.9)8.1 (14.6)–4.1 (–7.9, –0.2)Hospitalization-free survival (days)40.3 (29.8)28.4 (28.5)11.9 (4.9, 18.8)Conclusion: VOR pts had significantly longer hospitalization-freesurvival and had a trend toward fewer ICU days than CAB pts.Improved survival with less hospital resource utilization andlower total drug acquisition costs (Lewis JS et al, ICAAC 2003,A1359) support the economic benefit of using VOR for primarytherapy for AIA.Results: There were 143 and 131 pts in the VOR and CAB arms,respectively, with resource utilization data. Resource utilizationdata are presented in the Table.
Resource Utilization by Treatment ArmConclusion: VOR pts had significantly longer hospitalization-freesurvival and had a trend toward fewer ICU days than CAB pts.Improved survival with less hospital resource utilization andlower total drug acquisition costs (Lewis JS et al, ICAAC 2003,A1359) support the economic benefit of using VOR for primarytherapy for AIA.