Blood concentrations of dopexamine in patients during and after orthotopic liver transplantation.
Journal - British journal of clinical pharmacology (ENGLAND )
Blood concentrations of dopexamine were measured in five female patients during and after orthotopic liver transplantation. Each patient received a continuous infusion of the drug (2 micrograms kg-1 min-1), starting at induction of anaesthesia and finishing 48 h afterwards. Blood concentrations of dopexamine increased rapidly at the start of the infusion, to a mean (range) value of 64 (40-150) ng ml-1 after 20 min. Blood concentrations of dopexamine increased further during the anhepatic period of surgery, to 236 (180-410) ng ml-1. On reperfusion of the donor liver, concentrations of dopexamine decreased rapidly, reaching similar values to the maximum seen during the dissection period. Steady-state was not reached during either the dissection or anhepatic periods. From 1-2 h after revascularisation the mean (range) steady-state concentration was 85 (69-102) ng ml-1 corresponding to a mean (range) clearance of 24 (20-29) ml min-1 kg -1. These results suggest that the liver plays a significant role in the clearance of dopexamine.
|ISSN : ||0306-5251|
|Mesh Heading : ||Adult Dopamine Female Humans Liver Middle Aged Vasodilator Agents blood pharmacokinetics pharmacokinetics|
|Mesh Heading Relevant : ||Liver Transplantation analogs & derivatives metabolism blood|
A comparison of dopexamine and dopamine to prevent renal impairment in patients undergoing orthotopic liver transplantation.
Journal - Anaesthesia (ENGLAND )
The efficacy of low-dose dopamine as a renal protective agent was compared with that of dopexamine in patients who underwent orthotopic liver transplantation. Twelve patients who received a continuous infusion of dopexamine (1-3 micrograms/kg/minute) were matched for age, diagnosis, pre-operative creatinine clearance and blood loss with 12 patients who received a low-dose infusion of dopamine (2 micrograms/kg/minute). The catecholamine infusion was started after induction of anaesthesia and continued for 48 hours after surgery. Patients in the dopexamine group had less evidence of renal impairment and failure than those in the dopamine group during 7 days after the operation, although the differences between groups did not achieve statistical significance. Similarly there were no significant differences between the two groups in peri-operative urine output, urine/plasma osmolality ratio or creatine clearance. Dopexamine is at least as effective as dopamine for renal protection in patients who undergo liver transplantation.
|ISSN : ||0003-2409|
|Mesh Heading : ||Adrenergic Agonists Adult Creatinine Dopamine Female Humans Kidney Failure, Acute Male Middle Aged Osmolar Concentration Postoperative Complications Urine urine|
|Mesh Heading Relevant : ||Liver Transplantation therapeutic use analogs & derivatives therapeutic use prevention & control prevention & control|