Prevalence of hypercalcitoninemia in patients on maintenance dialysis referred to kidney transplantation.
Journal - Clinical nephrology (Germany )
AIMS: Elevated calcitonin concentrations in dialysis patients had led to thyroidectomy for a benign C-cell hyperplasia in dozens of patients in the past decade. The prevalence of hypercalcitoninemia, however, has not been examined in a large cohort of dialysis patients. METHODS: We, therefore, measured calcitonin concentrations in 283 dialysis patients. We used different reference intervals: according to the threshold to perform further stimulation tests (i.e. > 10 pg/ml) and new reference intervals for the currently used assay (i.e. serum calcitonin concentration < 11.5 pg/ml in men and < 4.6 pg/ml in women). RESULTS: Median calcitonin concentrations of men and women were 12 (1; 290) pg/ml vs 2 pg/ml (1; 45), respectively, (p < 0.0001). The prevalence of hypercalcitoninemia was 10% in women and 58% in men using a cut-off of 10 pg/ml. Applying the new reference intervals 31% of women and 54% of men presented with hypercalcitoninemia. All patients with basal calcitonin concentrations above 50 pg/ml were men (highest calcitonin concentration was 290 pg/ml). Two of them underwent thyroidectomy and had C-cell hyperplasia. CONCLUSION: The prevalence of hypercalcitoninemia in dialysis patients amounts to 46%. It is more common in male than in female dialysis patients.
|ISSN : ||0301-0430|
|Mesh Heading : ||Austria Calcitonin Carcinoma, Medullary Chemiluminescent Measurements Female Humans Kidney Failure, Chronic Male Middle Aged Prevalence Prognosis Renal Dialysis Retrospective Studies Thyroid Neoplasms Thyroidectomy Tumor Markers, Biological epidemiology blood etiology blood complications blood etiology|
|Mesh Heading Relevant : ||Kidney Transplantation blood epidemiology therapy methods epidemiology blood|