Tracing the origin of Brazilian HTLV-1 as determined by analysis of host and viral genes.
Journal - AIDS (London, England) (England )
We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu-Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence rate in KZN was 1.7%. All sequences belonged to the A subgroup. The presence of South African sequences in two different clusters from Brazil, and the finding of the beta-globin haplotype in infected hosts are consistent with the transmission of this virus from southern Africa to Brazil.
|ISSN : ||0269-9370|
|Mesh Heading : ||Brazil Epidemiology, Molecular Genetic Variation Globins HTLV-I Infections Haplotypes Human T-lymphotropic virus 1 Humans Phylogeny Seroepidemiologic Studies South Africa Terminal Repeat Sequences epidemiology methods genetics epidemiology|
|Mesh Heading Relevant : ||Evolution, Molecular Genes, Viral genetics genetics|
Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
Journal - AIDS research and human retroviruses (United States )
In Brazil, HTLV-2 has been detected in blood donors, in intravenous drug users (IDUs) from urban areas, and in Amerindians living in the Amazon basin. Of the three main HTLV-2 subtypes (2a, 2b, and 2d) only subtype 2a has been detected in Brazil. However, a molecular variant of subtype 2a (also called HTLV-2c) characterized by an extended Tax protein has been isolated from Brazilian blood donors, IDUs, and Indians. Here, we analyzed HTLV-2 isolates from 10 IDUs and a Chilean woman living in Salvador, Bahia, Brazil. Sequencing of env, pX, and long terminal repeat (LTR) genes demonstrated that 10 of the isolates are related to the Brazilian subtype 2a molecular variant described previously. We show that most HTLV-2a Brazilian strains comprise a phylogenetic group harboring a considerable degree of diversity within the env region but not within the LTR region. Interestingly, we demonstrated for the first time in Brazil the presence of a subtype 2a in IDUs that is closely related to the prototype Mo but distinct from the Brazilian 2a molecular variant.
|ISSN : ||0889-2229|
|Mesh Heading : ||Adult Brazil Europe Female Gene Products, env HTLV-II Infections Human T-lymphotropic virus 2 Humans Male Molecular Sequence Data North America Phylogeny Retroviridae Proteins, Oncogenic Sequence Analysis, DNA Substance Abuse, Intravenous Terminal Repeat Sequences epidemiology epidemiology chemistry genetics virology genetics epidemiology chemistry genetics genetics|
|Mesh Heading Relevant : ||Indians, South American epidemiology classification complications|