[Correlations between clinical and histological aspects in nasal polyposis]
(2008)
Journal - Acta otorrinolaringológica española (Spain )
Abstract :
INTRODUCTION: The histological study of nasal polyps does not reveal any specific lesions but eosinophilic infiltration nasal mucosae seems to be characteristic of nasal polyposis. The aim of this work is to study possible links between certain histological and clinical aspects in nasal polyposis. Furthermore, we attempt to compare the quantification of tissue eosinophilia according to the number of eosinophils per field with the percentage figure obtained with respect to the total of inflammatory cells. MATERIAL AND METHOD: We have studied 40 patients with idiopathic bilateral nasal polyposis, assessing the correlations between various clinical aspects such as their endoscopic and radiological status, association with asthma and intolerance to NSAIDs, against histological aspects of nasal polyps such as the frequency of metaplasia, fibrosis and the degree of eosinophilic infiltration. A group of 12 healthy subjects allowed comparison of our results with healthy nasal mucosa. RESULTS: Tissue eosinophilia correlates statistically with clinical staging and tends to be higher in patients with ASA triad. The quantitative measurement of tissue eosinophilia (number of eosinophils per field) correlates with the percentage figure obtained (with respect to the total number of inflammatory cells in the infiltrate). CONCLUSIONS: Eosinophil infiltration of the nasal mucosa is, together with oedema, the most constant histological characteristic of nasal polyposis and seems to be an important factor in the clinical behaviour of sinonasal polyposis. Quantitative measurement of tissue eosinophilia is easier and quicker to perform and equivalent to percentage evaluation.
[Granular cell tumor (Abrikossoff's tumor). A review and our experience]
(1992)
Journal - Anales otorrinolaringológicos ibero-americanos (SPAIN )
Abstract :
The low incidence of these tumors compelled the AA., after diagnosis of one of laryngeal sitting, to a review of the theme and its literature as well, particularly under the viewpoint of its histogenesis, which has been debatable up to lately. The report is complemented with the study of immunohistochemical tests for NHK, S-100 and specific neural enolase of the specimen.
| ISSN : | 0303-8874 |
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| Mesh Heading : | Adult Female Humans Larynx Male Middle Aged Syndrome Terminology as Topic pathology pathology pathology pathology |
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| Mesh Heading Relevant : | Granular Cell Tumor Laryngeal Neoplasms Neoplasms, Muscle Tissue |
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[Determination of the phase of synthesis by means of bromodeoxyuridine. Its clinical application in oncology of the head and neck]
(1992)
Journal - Anales otorrinolaringológicos ibero-americanos (SPAIN )
Abstract :
Tumour cell kinetics properties studied by the bromodeoxyuridine method, are useful in the prognosis and therapeutic planning of oncologic patients. In this paper the AA. review some clinical applications of this method, with special emphasis on head and neck tumours.
| ISSN : | 0303-8874 |
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| Mesh Heading : | Bromodeoxyuridine Cell Division DNA, Neoplasm Flow Cytometry Head and Neck Neoplasms Humans Immunohistochemistry Microscopy, Fluorescence S Phase physiology biosynthesis |
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| Mesh Heading Relevant : | pharmacokinetics metabolism physiology |
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[Olfactory neuroblastoma. A clinical and morphological study]
(1991)
Journal - Acta otorrinolaringológica española (SPAIN )
Abstract :
A clinical and morphological study about neuroblastoma with olfactory differentiation are made. This study includes: TAC, vanimil mandelic acid urine determination, optic microscope, immunohistochemical technique, neuropeptidal, in situ hybridization, DNA analysis by flow cytometry and electronic microscope.
| ISSN : | 0001-6519 |
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| Mesh Heading : | Combined Modality Therapy Humans Immunohistochemistry Male Neuroectodermal Tumors, Primitive, Peripheral Nose Neoplasms Olfactory Mucosa classification pathology therapy classification pathology therapy metabolism pathology |
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| Mesh Heading Relevant : | diagnosis diagnosis |
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[Pathogenic mechanisms of Pseudomonas aeruginosa in chronic suppurative otitis media]
(1991)
Journal - Acta otorrinolaringológica española (SPAIN )
Abstract :
The increased frequency of Pseudomonas aeruginosa in suppurative chronic otitis media makes this bacillus interesting. We consider the biological pathogenic and biochemical mechanisms, as well as some aspects of the interaction between PA and antibiotic therapy.
| ISSN : | 0001-6519 |
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| Mesh Heading : | Chronic Disease Drug Resistance, Microbial Humans Otitis Media, Suppurative Pseudomonas aeruginosa drug therapy drug therapy |
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| Mesh Heading Relevant : | Pseudomonas Infections microbiology pathogenicity |
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