Effects of different levels of food restriction on passive-avoidance memory and the expression of synapsin I in young mice.
Journal - The International journal of neuroscience (United States )
The present study investigated the effects of food restriction (FR) on memory and the expression of synapsin I in the brain of young mice. The results showed that 20% FR did not retard the body weight gain of mice, while the 60% and 80% FR reduced the mice's body weight. The memory after 24 hr of learning was not changed by FR, whereas long-term memory was improved significantly in 20% FR mice. In addition, 60% and 80% FR did not impair the mice's memory. The transcriptional expression of synapsin I in mice brain was up-regulated by 20% FR, and down-regulated by 60% and 80% FR.
|ISSN : ||1563-5279|
|Mesh Heading : ||Aging Animals Avoidance Learning Body Weight Brain Caloric Restriction Down-Regulation Food Deprivation Male Memory Memory Disorders Mice Synapsins Up-Regulation metabolism physiology methods physiology metabolism physiopathology therapy physiology|
|Mesh Heading Relevant : ||physiology growth & development metabolism physiology physiology metabolism|
Effects of food deprivation on expression of growth hormone receptor and proximate composition in liver of black seabream Acanthopagrus schlegeli.
Journal - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (England )
The effects of food deprivation on the hepatic level growth hormone receptor (GHR) were investigated in black seabream (Acanthopagrus schlegeli) both at the protein level (by radioreceptor assay) and at the mRNA level (by ribonuclease protection assay). Serum levels of growth hormone (GH) and triiodothyronine (T(3)) were also measured. Condition factor and hepatic proximate composition of the fish were also assessed. Significant decrease in hepatic GHR binding was recorded as early as on day 2 of starvation. On day 30 this decrease was even more pronounced, with the level in the starved fish reaching less than 20% the fed control level. A concomitant decrease in the hepatic GHR mRNA content was also noted during this period, with a progressive decrease from day 2 to day 30 of starvation. The extent of decrease in the mRNA content was less pronounced than the decrease in receptor binding, with the hepatic GHR mRNA content in the day 30 starved fish representing approximately 30% of the level in the fed control. In large contrast, serum GH level increased progressively during starvation. After 30 days of starvation, serum GH levels in the starved fish were more than three times the concentration found in the fed control. Serum T(3) levels, on the other hand, decreased during starvation, with the difference reaching significance on day 15 and day 30. After 30 days of starvation, serum T(3) levels in the starved fish were only approximately 40% the concentration found in the fed control. The hepatic lipid content exhibited an increasing trend during starvation. On day 30 the hepatic lipid content of the starved fish had doubled the level found in the fed control. However, the hepatic protein content did not exhibit much change during starvation. There was also a minor decrease in the moisture content of the liver during starvation, but the condition factor of the fish as a whole registered a gradual decrease during the course of food deprivation.
|ISSN : ||1096-4959|
|Mesh Heading : ||Animal Nutritional Physiological Phenomena Animals Dietary Fats Dietary Proteins Growth Hormone Liver RNA, Messenger Radioimmunoassay Receptors, Somatotropin Sea Bream Starvation Time Factors Triiodothyronine metabolism metabolism blood metabolism metabolism blood metabolism blood|
|Mesh Heading Relevant : ||Food Deprivation Gene Expression metabolism blood|