The conjunctival impression cytology between the diagnosed cases of dry eye and normal individuals.
(2011)
Journal - Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH (Nepal )
Abstract :
Background: The dry eye or tear film dysfunction is a common ophthalmic syndrome. Objective: To compare the results of conjunctival impression cytology between dry eye patients and normal individuals. Subjects and methods: A case control study including consecutive cases of dry eye syndrome was carried out. Individuals without dry eye were taken as control. Impression of conjunctiva with cellulose acetate filter paper was taken from inferonasal bulbar conjunctiva and was stained with Periodic Acid- Schiff (PAS) and counter-stained with haematoxylin and eosin. Main outcome measure: goblet cell density. Results: There was a female preponderance in dry eye disease. Of 114 dry eye cases, 49.2% eyes showed decreased or absent goblet cell density. In 72 normal individuals 73.7% eyes showed normal goblet cell density and 26.3% of eyes showed decreased or absent goblet cells (p less than 0.001). The tear break-up time (TBUT) test was significantly more likely to be less than 10 seconds in cases as compared to the controls ( OR = 19.36, 95% CI = 7.56 - 52.52). Similarly, the goblet cell density was likely to be significantly reduced in cases with dry eye syndrome (OR= 2.25, 95% CI = 1.26 - 4.02, p = 0.003). Conclusion: Goblet cell density significantly reduces in dry eye syndrome. The impression cytology is a useful test for the diagnosis of dry eye syndrome. Key words: impression cytology; conjunctiva; dry eyes; tear film.© NEPjOPH.
A profile and treatment outcome of seasonal hyper-acute panuveitis.
(2010)
Journal - Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH (Nepal )
Abstract :
Seasonal hyper-acute panuveitis (SHAPU) is a sight-threatening disease and its management is challenging.To study the profile and evaluate the visual outcome of the patients of clinically-diagnosed cases of SHAPU after treatment.A retrospective interventional hospital-based study was carried out involving 21 subjects with clinically-diagnosed SHAPU. The data were retrieved from the record section of the hospital and analyzed. The variables studied were demographic pattern, clinical condition, duration of presentation and visual acuity before and after the treatment.The data were analyzed using Epi Info version 2000. Percentage prevalence, mean values with standard deviation, relative risk, 95% CI and p value were calculated. P value of < 0.05 was considered to be significant.Among the 21 cases, the numbers of male and female were 11 (52.4 %) and 10 (46.7%) respectively. A comparative analysis of gender in children and adults did not show any significant difference (RR = 0.47, 95% CI = 0.22 - 1.01, Fisher exact test: p = 0.14). The mean for all ages was 7 +/- 12.68 years, while the mean age in pediatric cases was 4.5 +/- 3.91 years. Thirteen (61.9%) cases occurred in children below fifteen years. Fifteen (71.4%) cases reported during September and October. Presenting visual acuity of all cases was less than 3/60. All of them received medical treatment. By the end of the 41 week, seven (33.3%) patients regained vision to 6/18.SHAPU is more prevalent in pediatric age group. It is equally prevalent among males and females. The visual acuity can improve with early medical treatment.