Mathematical modeling of planar cell polarity to understand domineering nonautonomy.
(2005)
Journal - Science (New York, N.Y.) (United States )
Abstract :
Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here, a contact-dependent signaling hypothesis, derived from experimental results, is shown by reaction-diffusion, partial differential equation modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy.
| ISSN : | 1095-9203 |
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| Mesh Heading : | Adaptor Proteins, Signal Transducing Alleles Animals Cell Membrane Diffusion Drosophila Drosophila Proteins Feedback, Biochemical Frizzled Receptors Mathematics Membrane Proteins Mutation Phenotype Phosphoproteins Protein Binding Receptors, G-Protein-Coupled Wing metabolism genetics metabolism genetics metabolism genetics metabolism genetics metabolism metabolism |
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| Mesh Heading Relevant : | Cell Polarity Models, Biological Signal Transduction cytology cytology |
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Mathematical Modeling of Planar Cell Polarity to Understand Domineering Nonautonomy
(2005)
Journal - Science
Abstract :
Planar cell polarity (PCP) signaling generates subcellular asymmetryalong an axis orthogonal to the epithelial apical-basal axis.Through a poorly understood mechanism, cell clones that havemutations in some PCP signaling components, including some,but not all, alleles of the receptor frizzled, cause polaritydisruptions of neighboring wild-type cells, a phenomenon referredto as domineering nonautonomy. Here, a contact-dependent signalinghypothesis, derived from experimental results, is shown by reaction-diffusion,partial differential equation modeling and simulation to fullyreproduce PCP phenotypes, including domineering nonautonomy,in the Drosophila wing. The sufficiency of this model and theexperimental validation of model predictions reveal how specificprotein-protein interactions produce autonomy or domineeringnonautonomy.* These authors contributed equally to this work.