Basic Biological Sciences
Journal - Journal of Dental Research
Thirty-two strains of Lactobacilli, comprising eight speciesand obtained from human dental plaque or other sources, weretested for cariogenic potential in gnotobiotic Sprague-Dawleyrats receiving modified cariogenic Diet 2000. Seventeen of thesestrains were moderately to highly cariogenic, and only one,a strain of Lactobacillus lactis, was scored as non-cariogenic.The molar fissures were the predominant site of caries attack.Primary lesions of the smooth surfaces were infrequently seen,although these surfaces were often secondarily involved by theextension of fissure lesions. The preferential location of cariesin the sheltered fissure sites was attributed to their inabilityto form adherent plaque deposits on the smooth surfaces of theteeth. Caries production by a strain of L. salivarius was equallysevere on sucrose- or glucose-containing versions of Diet 2000,but glucose was less supportive of caries development than sucrosefor a strain of L. fermentum. It is concluded that a wide varietyof lactobacilli may be cariogenic under favorable environmentalconditions.