Folkert O Belzer

Title PROFESSOR AND CHAIRMAN

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

Address Show details

Share |

Keywords

BLOOD TOXICOLOGY, BACTEREMIA - SEPTICEMIA, HEALTH CARE SERVICES, REHABILITATION NONPSYCHOSOCIAL, KIDNEY-CIRCULATORY DISORDERS, MENTAL HEALTH SERVICES, REHABILITATION PSYCHOSOCIAL, PARATHYROID HORMONES, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING, TISSUE COMPATIBILITY-TRANSPLANT, ISOALLOIMMUNITY, TISSUE DONORS, TISSUE PRESERVATION, kidney transplantation ARTHRITIS AND METABOLIC DISEASES PROGRAM PROJECT COMMITTEE, BLOOD AND RE SYSTEM, MACROPHAGES, BLOOD CELLS, LEUKOCYTES, BLOOD CELLS, LYMPHOCYTES, BLOOD TREATMENT, HEMODIALYSIS, CARBOHYDRASES, NEURAMINIDASE, CARDIOVASCULAR DISORDERS, HYPERTENSION (SYSTEMIC), CHILDREN, DEATH, POST-MORTEM, FUNGI, YEASTS, CANDIDA ALBICANS*, IMMUNITY, IMMUNOSUPPRESSION, ALLOANTISERA, KIDNEY FUNCTION, DIURETICS, KIDNEY FUNCTION, SALURESIS, KIDNEY NEOPLASMS, PHENOXYACETIC ACIDS, 2,3-DICHLORO-4-(2-METHYLBUTYL)PHENOXYACETIC ACID, POPULATION STUDIES HUMAN, LONGITUDINAL STUDY, SUGAR ALCOHOLS, HEXITOLS, MANNITOL, TISSUE (CELL) CULTURE, MIXED CULTURES, TISSUE COMPATIBILITY-TRANSPLANT, TRANSPLANTATION HOMOLOGOUS IMMUNOLOGICAL TESTS AND IMMUNOASSAY, IMMUNOASSAY*

Summary Information

Recipient of US government research funding (8)

8,306,749

Maven is an online database of international healthcare professionals. Records are downloadable to Excel or in-house database, with email, postal address and phone/fax contacts.

To view and export full contact details of healthcare professionals you must subscribe to Maven Semantic. To learn more please request a call from our team:

Request a call Brochure

People in the same organisation:

USA Grants

PATHOPHYSIOLOGY OF CLINICAL ORGAN TRANSPLANTATION

(1976)

Project Number :	2P01AM011290-06
ICD :	NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
IRG :	AMP
Project Terms :	BLOOD TOXICOLOGY, BACTEREMIA - SEPTICEMIA, HEALTH CARE SERVICES, REHABILITATION NONPSYCHOSOCIAL, KIDNEY-CIRCULATORY DISORDERS, MENTAL HEALTH SERVICES, REHABILITATION PSYCHOSOCIAL, PARATHYROID HORMONES, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING, TISSUE COMPATIBILITY-TRANSPLANT, ISOALLOIMMUNITY, TISSUE DONORS, TISSUE PRESERVATION, kidney transplantation ARTHRITIS AND METABOLIC DISEASES PROGRAM PROJECT COMMITTEE, BLOOD AND RE SYSTEM, MACROPHAGES, BLOOD CELLS, LEUKOCYTES, BLOOD CELLS, LYMPHOCYTES, BLOOD TREATMENT, HEMODIALYSIS, CARBOHYDRASES, NEURAMINIDASE, CARDIOVASCULAR DISORDERS, HYPERTENSION (SYSTEMIC), CHILDREN, DEATH, POST-MORTEM, FUNGI, YEASTS, CANDIDA ALBICANS, IMMUNITY, IMMUNOSUPPRESSION, ALLOANTISERA, KIDNEY FUNCTION, DIURETICS, KIDNEY FUNCTION, SALURESIS, KIDNEY NEOPLASMS, PHENOXYACETIC ACIDS, 2,3-DICHLORO-4-(2-METHYLBUTYL)PHENOXYACETIC ACID, POPULATION STUDIES HUMAN, LONGITUDINAL STUDY, SUGAR ALCOHOLS, HEXITOLS, MANNITOL, TISSUE (CELL) CULTURE, MIXED CULTURES, TISSUE COMPATIBILITY-TRANSPLANT, TRANSPLANTATION HOMOLOGOUS IMMUNOLOGICAL TESTS AND IMMUNOASSAY, IMMUNOASSAY

PATHOPHYSIOLOGY OF CLINICAL ORGAN TRANSPLANTATION

(1976)

Project Number :	5P01AM011290-07
ICD :	NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
IRG :	AMP
Project Terms :	BLOOD TOXICOLOGY, BACTEREMIA - SEPTICEMIA, HEALTH CARE SERVICES, REHABILITATION NONPSYCHOSOCIAL, KIDNEY-CIRCULATORY DISORDERS, MENTAL HEALTH SERVICES, REHABILITATION PSYCHOSOCIAL, PARATHYROID HORMONES, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING, TISSUE COMPATIBILITY-TRANSPLANT, ISOALLOIMMUNITY, TISSUE DONORS, TISSUE PRESERVATION, kidney transplantation ARTHRITIS AND METABOLIC DISEASES PROGRAM PROJECT COMMITTEE, BLOOD AND RE SYSTEM, MACROPHAGES, BLOOD CELLS, LEUKOCYTES, BLOOD CELLS, LYMPHOCYTES, BLOOD TREATMENT, HEMODIALYSIS, CARBOHYDRASES, NEURAMINIDASE, CARDIOVASCULAR DISORDERS, HYPERTENSION (SYSTEMIC), CHILDREN, DEATH, POST-MORTEM, FUNGI, YEASTS, CANDIDA ALBICANS, IMMUNITY, IMMUNOSUPPRESSION, ALLOANTISERA, KIDNEY FUNCTION, DIURETICS, KIDNEY FUNCTION, SALURESIS, KIDNEY NEOPLASMS, PHENOXYACETIC ACIDS, 2,3-DICHLORO-4-(2-METHYLBUTYL)PHENOXYACETIC ACID, POPULATION STUDIES HUMAN, LONGITUDINAL STUDY, SUGAR ALCOHOLS, HEXITOLS, MANNITOL, TISSUE (CELL) CULTURE, MIXED CULTURES, TISSUE COMPATIBILITY-TRANSPLANT, TRANSPLANTATION HOMOLOGOUS IMMUNOLOGICAL TESTS AND IMMUNOASSAY, IMMUNOASSAY

PATHOPHYSIOLOGY OF CLINICAL ORGAN TRANSPLANTATION

(1976)

Project Number :	3P01AM011290-07S1
ICD :	NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
IRG :	AMP

PATHOPHYSIOLOGY OF CLINICAL ORGAN TRANSPLANTATION

(1976)

Abstract :

Our approach to renal transplantation will be directed towards five main goals: 1. With the establishment of a new dialysis center and greater participation of the Department of Medicine in the field of transplantation we are planning to increase our clinical activities from an average of 110 transplants per year to between 160-180 per year. 2. To identify by a combination of HL-A phenotyping and multiple lymphocyte culture the best possible donor-recipient combination. MLCs are now used prospectively to select living related donor-recipient pairs but retrospectively for cadaver kidneys. 3. To investigate improved methods of immunosuppressive therapy. Combination therapy of lmuran and Cytoxan are being studied at the present time as well as the effectiveness ober highly potent well standardized primate tested anti-thymocyte globulin in recipients of cadaver kidneys. 4. To extend the period of organ preservation prior to transplantation to allow the use of MLC prospectively in cadaver kidney transplants. 5. To perform transplantation with the lowest mortality rate possible.

Project Number :	5P01AM011290-08
ICD :	NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
IRG :	AMP
Project Terms :	ARTHRITIS AND METABOLIC DISEASES PROGRAM PROJECT COMMITTEE, IMMUNITY, IMMUNOSUPPRESSION, ALLOANTISERA, IMMUNOPATHOLOGY, CHEMOTHERAPY, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING, TISSUE COMPATIBILITY-TRANSPLANT, ISOALLOIMMUNITY, TISSUE DONORS, TISSUE PRESERVATION, kidney transplantation ADRENAL CORTEX HORMONES ANALOGS, PREDNISONE, BIOMEDICAL ENGINEERING, INSTRUMENTATION CLINICALLY ORIENTED, BLOOD CELLS, LYMPHOCYTES, BLOOD TREATMENT, HEMODIALYSIS, CHILDREN, CONNECTIVE TISSUE DISORDERS, LUPUS ERYTHEMATOSUS SYSTEMIC, DEATH, CADAVER (TISSUE), DRUGS INTERACTION, HALOALKYLAMINES, CYCLOPHOSPHAMIDE, IMMUNITY, IMMUNOSUPPRESSIVE AGENTS, MAMMALS, METABOLIC DISORDERS (INBORN) DIABETES, JUVENILE, POPULATION STUDIES HUMAN, LONGITUDINAL STUDY, THIOPURINES, 6-MERCAPTOPURINE, AZATHIOPRINE, TISSUE COMPATIBILITY-TRANSPLANT, TRANSPLANTATION HOMOLOGOUS HUMAN, CLINICAL, IMMUNOLOGICAL TESTS AND IMMUNOASSAY, IMMUNOASSAY*, TISSUE COMPATIBILITY-TRANSPLANT, HISTOCOMPATIBILITY TYPING,CML

STUDIES IN ORGAN PRESERVATION

(1974)

Abstract :

Although canine kidneys can be stored successfully for up to 3 days by continuous pulsatile perfusion with cryo-precipitated plasma at 10 degrees C there is continued deterioration of renal reserve during this period of storage. Thus, dogs receiving kidneys stored for 24 hours will have lower serum creatinines in the postoperative period than kidneys stored for 72 hours. The exact mechanism of this deterioration is unknown and actually may be due to several different causes. Thus, substrate utilization may play a key factor. Our studies so far have shown -hydroxy-butyrate added can account for over 68 percent of the oxygen consumption of the tissues, but we are not able as yet to supply all metabolic fuel by the addition of a single substrate during hypothermic metabolism of the kidney cortex. Thus, endogenous substrate utilization continues and by itself could be the cause of many problems. Thus, exhaustion of endogenous substrate may play a role as oxidation of substrates such as lipids may cause direct harm by its effect on cellular membranes. We are planning to continue our investigations in the substrate utilization in both 38 degrees as well as 10 degrees C until we have found the mixture of substrates that will prevent utilization of endogenous substrates. Substrate utilization will be studied both aerobically as well as anaerobically. As anaerobic perfusion will prevent the obligatory activation of respiratory enzymes, this may be the preferred method for long-term storage. The search will continue, therefore, to attempt to provide the kidney cortex with substrate that can be utilized anaerobically. Finally, as one of the main problems in long-term storage may actually lie in hypothermia, perfusion at higher temperatures will be continued. This would prevent some of the physical changes which occur in the cell membranes of homeotherms, such as dog and man under conditions of hypothermia and also would eliminate the problems of cold sensitivity of certain essential enzyme systems. It still appears to be even more essential at the present time to obtain consistent long-term preservation (7 days or more) as evidence accumulating that the mixed lymphocyte culture reaction may indeed be the preferred method for donor/recipient matching, and that a breakthrough in clinical renal transplantation may not come until long- term preservation has been accomplished.

Project Number :	5R01AM014696-03
ICD :	NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
IRG :	SGYB
Project Terms :	SURGERY STUDY SECTION, TISSUE PRESERVATION, kidney transplantation BODY FLUID BALANCE, IONIC, DOSAGE AND ROUTE, ISOLATION-PERFUSION, PHOSPHATASES, ADENOSINE TRIPHOSPHATASE, TEMPERATURE (BODY), HYPOTHERMIA MAMMALS, CARNIVORES, DOGS, OPTICS, MICROSCOPY, ELECTRON

STUDIES IN ORGAN PRESERVATION

(1974)

Project Number :	1R01AM014696-01A1
ICD :	NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
IRG :	SGYB

STUDIES IN ORGAN PRESERVATION

(1974)

Project Number :	5R01AM014696-02
ICD :	NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
IRG :	SGYB
Project Terms :	DOSAGE AND ROUTE, ISOLATION-PERFUSION, TISSUE PRESERVATION BIOMEDICAL ENGINEERING, INSTRUMENTATION CLINICALLY ORIENTED, BODY FLUID BALANCE, IONIC, CARDIOVASCULAR AGENTS, VASODILATORS, HEART, LIVER, PHOSPHATASES, ADENOSINE TRIPHOSPHATASE, SURGERY STUDY SECTION, TEMPERATURE (BODY), HYPOTHERMIA, kidney transplantation MAMMALS, CARNIVORES, DOGS, MAMMALS, UNGULATES, SWINE, OPTICS, MICROSCOPY, ELECTRON*

EVALUATION OF ALG AS AN IMMUNOSUPPRESSIVE AGENT

(1974)

Project Number :	2N01AI022540-00472
ICD :	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES