Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
Journal - Journal of immunology (Baltimore, Md. : 1950) (UNITED STATES )
The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing to the immunosuppression observed after HIV infection. Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response.
|ISSN : ||0022-1767|
|Mesh Heading : ||Animals Cytoplasm HIV HIV Envelope Protein gp120 Humans Immunosuppressive Agents Interleukin-2 Mice Phenotype Retroviridae Proteins T-Lymphocytes Viral Envelope Proteins immunology immunology biosynthesis classification|
|Mesh Heading Relevant : ||Antigens, Differentiation, T-Lymphocyte immunology physiology physiology metabolism physiology|
MHC RESTRICTION OF VSV G PROTEIN SPECIFIC T-CELLS
|Project Number : || 1F32AI007843-01|
|ICD : ||NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES|
|IRG : ||CLN|