Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
(1988)
Journal - Journal of immunology (Baltimore, Md. : 1950) (UNITED STATES )
Abstract :
The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing to the immunosuppression observed after HIV infection. Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response.
| ISSN : | 0022-1767 |
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| Mesh Heading : | Animals Cytoplasm HIV HIV Envelope Protein gp120 Humans Immunosuppressive Agents Interleukin-2 Mice Phenotype Retroviridae Proteins T-Lymphocytes Viral Envelope Proteins immunology immunology biosynthesis classification |
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| Mesh Heading Relevant : | Antigens, Differentiation, T-Lymphocyte immunology physiology physiology metabolism physiology |
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MHC RESTRICTION OF VSV G PROTEIN SPECIFIC T-CELLS
(1988)
| Project Number : | 1F32AI007843-01 |
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| ICD : | NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES |
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| IRG : | CLN |
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